Articles liés à Acute lymphoblastic leukemia (ALL) and interferon beta-1...

Acute lymphoblastic leukemia (ALL) and interferon beta-1 gene: Mutational analysis of Interferon beta 1 (IFNβ1) gene in blood cancer patients of Acute Lymphoblastic Leukemia (ALL) - Couverture souple

Kanwal, Madiha; Khan, Muhammad Jawad; Shakoori, Abdul Rauf

 
9783659230417: Acute lymphoblastic leukemia (ALL) and interferon beta-1 gene: Mutational analysis of Interferon beta 1 (IFNβ1) gene in blood cancer patients of Acute Lymphoblastic Leukemia (ALL)
Couverture souple
ISBN 10 : 3659230413 ISBN 13 : 9783659230417
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of early non-granular white blood cells, or lymphoblasts. ALL occurs predominantly in children, peaking at 4 years of age. Interferons (IFNs) are the biological agents involved in the antiviral responses and the inhibition of tumor growth. In oncology, the IFNs are an important treatment options for a number of solid tumors and hematological malignancies. The IFN-β1gene consists of 840 bp and it lacks intron sequences. Seventy patients suffering from Childhood Acute Lymphoblastic Leukemia were studied and analyzed for mutation analysis of IFN-β1. So, 58.3% of the patients suffering from ALL were observed and compared with 41.7% normal DNA samples as control. PCR was performed and amplified gene products were detected on agarose gel and PAGE. Finally, SSCP was performed and mobility shift was observed in 7 out of 70 ALL samples. We observed that ALL disease typically develops in children ages 1-10 years old and is more prevalent in males than females. Mutation in the IFN-β1 gene was significantly related to 1-5 years in case of association of mutation with age.

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Présentation de l'éditeur

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of early non-granular white blood cells, or lymphoblasts. ALL occurs predominantly in children, peaking at 4 years of age. Interferons (IFNs) are the biological agents involved in the antiviral responses and the inhibition of tumor growth. In oncology, the IFNs are an important treatment options for a number of solid tumors and hematological malignancies. The IFN-β1gene consists of 840 bp and it lacks intron sequences. Seventy patients suffering from Childhood Acute Lymphoblastic Leukemia were studied and analyzed for mutation analysis of IFN-β1. So, 58.3% of the patients suffering from ALL were observed and compared with 41.7% normal DNA samples as control. PCR was performed and amplified gene products were detected on agarose gel and PAGE. Finally, SSCP was performed and mobility shift was observed in 7 out of 70 ALL samples. We observed that ALL disease typically develops in children ages 1-10 years old and is more prevalent in males than females. Mutation in the IFN-β1 gene was significantly related to 1-5 years in case of association of mutation with age.

Biographie de l'auteur

Has obtained M.Phil from GCU Lahore, Pakistan. Expertise: Industrial Biotechnology and Molecular Biology. Muhammad Jawad Khan: PhD student in Animal Sciences UIUC USA. Expertise: Molecular Biology and Nutriphysiogenomics.Dr. Abdul Rauf Shakoori: Distinguished National Professor and professor Emeritus, University of the Punjab, Lahore Pakistan

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659230413
ISBN 13 
9783659230417
Reliure
Broché
Nombre de pages
172
Coordonnées du fabricant
non disponible
Personne responsable
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