Fast Dissolving Tablets Of Chlorpromazine And Promethazine: Fast Dissolving Tablets - Couverture souple

Ganesh Kumar, Gudas; Umamaheshwari, R.; Bhikshapathi, D.V.R.N

 
9783659232466: Fast Dissolving Tablets Of Chlorpromazine And Promethazine: Fast Dissolving Tablets
Couverture souple
ISBN 10 : 3659232467 ISBN 13 : 9783659232466
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Chlorpromazine HCl and Promethazine HCl are potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Fast dissolving tablets of Chlorpromazine HCl and Promethazine HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Chlorpromazine HCl and Promethazine HCl was prepared and studied and the formulation F2 and S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present study an attempt has been made to prepare fast dissolving tablets of Chlorpromazine HCl and Promethazine HCl, by using different superdisintegrants with enhanced disintegration and dissolution rate

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Chlorpromazine HCl and Promethazine HCl are potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Fast dissolving tablets of Chlorpromazine HCl and Promethazine HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Chlorpromazine HCl and Promethazine HCl was prepared and studied and the formulation F2 and S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present study an attempt has been made to prepare fast dissolving tablets of Chlorpromazine HCl and Promethazine HCl, by using different superdisintegrants with enhanced disintegration and dissolution rate

Biographie de l'auteur

Ganesh Kumar Gudas, M.Pharm (Ph.D) Assistant Professor, Department of Pharmaceutics, Srikrupa Institute of Pharmaceutical Sciences, Siddipet (A.P)India. He has over 8 research publications to his credit in national and international journals. His research interest extends from Novel Drug Delivery Systems to Delivery Aspects of Biopharmaceuticals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659232467
ISBN 13 
9783659232466
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
Personne responsable
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