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Physicochemical characterization & dissolution studies of Allopurinol: Solubility Enhancement of Poorly soluble Allopurinol - Couverture souple

Musale, Vinod

 
9783659232879: Physicochemical characterization & dissolution studies of Allopurinol: Solubility Enhancement of Poorly soluble Allopurinol
Couverture souple
ISBN 10 : 3659232874 ISBN 13 : 9783659232879
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The rate-limiting step to absorption of drugs from the gastrointestinal tract is often dissolution from the dosage form. Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with leukaemia, radiotherapy. One of the major problems with allopurinol is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study amphiphilic carrier like gelucire 50/13, PVP K30 & PEG 6000 are used in the ratio of 1:1, 1:2 and 1:4. Prepared solid dispersions were characterized in the liquid state by phase solubility studies and in the solid state by Differential Scanning calorimetric analysis, Powder X-ray diffractometry and Fourier Transform Infrared spectroscopy. The aqueous solubility of allopurinol was preferential by the presence polymer with increasing concentration. Solid state characterizations indicated that allopurinol was present as an amorphous material and entrapped in polymer matrix. Therefore, the current Research showed that gelucire 50/13 PVP K30 & PEG 6000 has a significant solubilizing effect on allopurinol.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The rate-limiting step to absorption of drugs from the gastrointestinal tract is often dissolution from the dosage form. Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with leukaemia, radiotherapy. One of the major problems with allopurinol is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study amphiphilic carrier like gelucire 50/13, PVP K30 & PEG 6000 are used in the ratio of 1:1, 1:2 and 1:4. Prepared solid dispersions were characterized in the liquid state by phase solubility studies and in the solid state by Differential Scanning calorimetric analysis, Powder X-ray diffractometry and Fourier Transform Infrared spectroscopy. The aqueous solubility of allopurinol was preferential by the presence polymer with increasing concentration. Solid state characterizations indicated that allopurinol was present as an amorphous material and entrapped in polymer matrix. Therefore, the current Research showed that gelucire 50/13 PVP K30 & PEG 6000 has a significant solubilizing effect on allopurinol.

Biographie de l'auteur

Vinod Musale,Vinod Born Aug 19,1984),Research Scholar & Scientist at Medisol Lifescience Pvt. Ltd., Gujarat (India),Vinod has earned Masters of Pharmacy (Quality Assurance)University of Pune on 2009 and stood 1st class all through academic results.Vinod has extensive exposer in P'ceutical Quality Assurance & Regulatory Affairs.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659232874
ISBN 13 
9783659232879
Reliure
Broché
Nombre de pages
152
Coordonnées du fabricant
non disponible
Personne responsable
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