Formulation And Evaluation Of Cinnarizine Floating Tablets: A Floating Type Approach of Gastro - retentive Tablet Dosage Form of Cinnarizine, An Anti Histaminic Drug - Couverture souple

Doshi, Sumit; Patil, Uma

 
9783659240973: Formulation And Evaluation Of Cinnarizine Floating Tablets: A Floating Type Approach of Gastro - retentive Tablet Dosage Form of Cinnarizine, An Anti Histaminic Drug
Couverture souple
ISBN 10 : 3659240974 ISBN 13 : 9783659240973
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Cinnarizine, a piperazine derivative with anti-histaminic activity finds its major use in control of vomiting due to motion sickness. It has a short half-life of 3-6 hrs. & the usual dosage regimen is 75 mg twice or three times a day for adults. The floating tablets of cinnarizine were formulated using varying concentration of HPMC K4M & effervescent agents by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio & drug content. The tablets were evaluated for thickness, hardness, weight variation test, friability, in vitro buoyancy & in vitro dissolution study. A 3 Square factorial design was used to study the effect of HPMC K4M & citric acid on lag time, floating time & percentage cumulative release. The responses were analyzed using ANOVA & by the predictive equation, it was found that the concentration of HPMC K4M & citric acid significantly affected all the response parameters. The obtained model was validated & optimized formulation was prepared as suggested by the software. All the predicted values of responses were found to be closed to the observed values.

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À propos de l?auteur

Bachelor of Pharmacy from J. S. S. College of Pharmacy, Ooty. Master of Pharmacy in Pharmaceutical Technology from Rajiv Gandhi University of Health Sciences, Karnataka. Pursuing Ph D from R. K. University, Rajkot. Attended 6 National Conferences & Presented 4 Posters at National Level. Published 4 International Publications in Reputed Journals.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659240974
ISBN 13 
9783659240973
Reliure
Broché
Nombre de pages
144
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
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