Solubility Enhancement Of Simvastatin By Using Surfactant HPMC: solubility enhancement of simvastatin - Couverture souple

Seema, Pattewar; Patil, Deepak

 
9783659243950: Solubility Enhancement Of Simvastatin By Using Surfactant HPMC: solubility enhancement of simvastatin
Couverture souple
ISBN 10 : 3659243957 ISBN 13 : 9783659243950
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Today, 35-40% of all new chemical entities suffer from poor aqueous solubility; hence the enhancement of the solubility of poorly water-soluble drug is one of the most challenging aspects of modern drug development. The aqueous solubility of a drug is an important molecular property that mainly influences the extent of its oral bioavailability. Due to their poor aqueous solubility many drug candidates became unsuccessful to reach in the market in spite of exhibiting potential pharmacodynamic properties. Therefore it is very useful to find appropriate formulation approach to improve aqueous solubility and thus bioavailability of poorly soluble drug. Poor bioavailability may also oblige the formulator to choose the injection route instead of the oral route. Injection route is costly. For good oral bioavailability drug must be soluble in gastro-intestinal fluids i.e. aqueous soluble and also possess permeability properties for good membrane diffusion in order to reach the bloodstream

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Présentation de l'éditeur

Today, 35-40% of all new chemical entities suffer from poor aqueous solubility; hence the enhancement of the solubility of poorly water-soluble drug is one of the most challenging aspects of modern drug development. The aqueous solubility of a drug is an important molecular property that mainly influences the extent of its oral bioavailability. Due to their poor aqueous solubility many drug candidates became unsuccessful to reach in the market in spite of exhibiting potential pharmacodynamic properties. Therefore it is very useful to find appropriate formulation approach to improve aqueous solubility and thus bioavailability of poorly soluble drug. Poor bioavailability may also oblige the formulator to choose the injection route instead of the oral route. Injection route is costly. For good oral bioavailability drug must be soluble in gastro-intestinal fluids i.e. aqueous soluble and also possess permeability properties for good membrane diffusion in order to reach the bloodstream

Biographie de l'auteur

BIO-DATA Name: Pattewar Seema Venkatrao (Patil)& Deepak patilQualification: M.Pharm Experience: academic field.Presently working in Sanjivani institute of pharmacy and research,Kopargaon,INDIA

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659243957
ISBN 13 
9783659243950
Reliure
Broché
Nombre de pages
88
Coordonnées du fabricant
non disponible
Personne responsable
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