Chemical Synthesis of Posttranslationally Modified Proteins: From Chemistry to Biology - Couverture souple

Yang, Renliang

Couverture souple

ISBN 10 : 3659247529 ISBN 13 : 9783659247521

Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Many proteins undergo extensive posttranslational modifications (PTMs), such as methylation, acetylation, phosphorylation, glycosylation and ubiquitination. To elucidate the roles of these PTMs, it is necessary to generate homogeneously modified proteins. In this book, we are going to introduce the recently developed chemical synthetic methods for the synthesis of proteins with certain PTM(s). First, we introduce a ligation/S-alkylation approach for the semisynthesis N-terminal tail acetylated proteins. Next, we also introduce the dual native chemical ligation at lysine method for the synthesis of ubiquitinated peptides and proteins. Finally, we introduce a novel N-to-C sequential ligation method for protein total synthesis. These methods developed have dramatically promoted protein PTM research.

A propos du livre

À propos de l'auteur

I completed my undergraduate studies in Biological Sciences at Nanyang Technological University with honors in 2007, and received my PhD in Chemical Biology and Biochemistry at the same university in 2012. During my PhD studies, I followed Dr Liu Chuan-Fa and focused on the study of chemical ligation and its application in protein synthesis.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3659247529
• ISBN 13: 9783659247521
• Reliure: Broché
• Nombre de pages: 156
• Coordonnées du fabricant: non disponible
• Personne responsable: KreGa Onlinehandel GmbH; 4950000000000; info@krega-onlinehandel.de; ; Birkenweg 31; Brakel; 33034; Allemagne