Vesicular Systems for Topical Fungal Infections: Basics, Development, Evaluation - Couverture souple

M., Senthil Kumar; Khatri, Meena

 
9783659249099: Vesicular Systems for Topical Fungal Infections: Basics, Development, Evaluation
Couverture souple
ISBN 10 : 3659249092 ISBN 13 : 9783659249099
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Superficial fungal infections are very common infections, approximately 90% of fungal skin infections are caused by dermatophytes-types of fungi. The present status of topical antifungal therapeutics like creams, gels, ointments etc., suffer from many drawbacks like severe blistering, itching, redness, peeling, dryness, or irritation of the skin and failed to achieve mycological eradication. To overcome the aforementioned limitations associated with conventional formulations, the novel vesicular carrier systems i.e. (liposomes, ethosomes, transfersomes) were being used. These carrier systems was preferred for topical drug delivery as these are biodegradable, biocompatible and nontoxic carrier as they composed of natural lipid, that was compatible with intercellular lipid lamellae within the skin layer. They also act as penetration enhancers owing the penetration of the individual lipid components into the stratum corneum. Amphotericin B (AmB) is most effective drug for the treatment of Mycosis infections. Hence, AmB loaded vesicular carrier systems were prepared and studied their relative potential for topical delivery of AmB for the treatment of fungal skin infections.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Superficial fungal infections are very common infections, approximately 90% of fungal skin infections are caused by dermatophytes-types of fungi. The present status of topical antifungal therapeutics like creams, gels, ointments etc., suffer from many drawbacks like severe blistering, itching, redness, peeling, dryness, or irritation of the skin and failed to achieve mycological eradication. To overcome the aforementioned limitations associated with conventional formulations, the novel vesicular carrier systems i.e. (liposomes, ethosomes, transfersomes) were being used. These carrier systems was preferred for topical drug delivery as these are biodegradable, biocompatible and nontoxic carrier as they composed of natural lipid, that was compatible with intercellular lipid lamellae within the skin layer. They also act as penetration enhancers owing the penetration of the individual lipid components into the stratum corneum. Amphotericin B (AmB) is most effective drug for the treatment of Mycosis infections. Hence, AmB loaded vesicular carrier systems were prepared and studied their relative potential for topical delivery of AmB for the treatment of fungal skin infections.

Biographie de l'auteur

Dr. Senthil Kumar is currently working as Professor and Head in the Department of Pharmaceutics, Nanomedicine Research Center, Rajendra Institute of Technology and Sciences, Institute of Pharmacy, Sirsa, Haryana, India

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659249092
ISBN 13 
9783659249099
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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