Development And Validation Of Analytical Methods: Simultaneous Estimation Of Amlodipine Besilate And Indapamide In Bulk Drug And Tablet Dosage Form - Couverture souple

Patel, Mehul; Shah, Rima

 
9783659256097: Development And Validation Of Analytical Methods: Simultaneous Estimation Of Amlodipine Besilate And Indapamide In Bulk Drug And Tablet Dosage Form
Couverture souple
ISBN 10 : 3659256099 ISBN 13 : 9783659256097
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Two UV-Spectrophotometric and RP-HPLC methods have been developed and validated for estimation of Amlodipine Besilate and Indapamide simultaneously.In absorbance correction method absorbance was measured at 360 nm for Amlodipine Besilate and at 242 nm for Indapamide. In First order Spectrophotometry method, the dA/dλ value in first order derivative spectra was measured at 242 nm for Amlodipine Besilate and 238 nm for Indapamide. The proposed methods were utilized for estimation of Amlodipine Besilate and Indapamide in tablet dosage form. RP-HPLC method showed adequate separation of Amlodipine Besilate and Indapamide. Amlodipine Besilate and Indapamide were estimated on C18 column using Acetonitrile: Water (contains 0.2% of Triethylamine and adjusting the pH to 4.0 with 10 % orthophosphoric acid) in a proportion of 70:30 v/v as mobile phase and detection was carried out at 238 nm. Results of Validation study and assay of all three methods were found to be satisfactory. The developed method were statistically compared using one way ANOVA which suggest that there is no significance difference among all three methods.

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Présentation de l'éditeur

Two UV-Spectrophotometric and RP-HPLC methods have been developed and validated for estimation of Amlodipine Besilate and Indapamide simultaneously.In absorbance correction method absorbance was measured at 360 nm for Amlodipine Besilate and at 242 nm for Indapamide. In First order Spectrophotometry method, the dA/dλ value in first order derivative spectra was measured at 242 nm for Amlodipine Besilate and 238 nm for Indapamide. The proposed methods were utilized for estimation of Amlodipine Besilate and Indapamide in tablet dosage form. RP-HPLC method showed adequate separation of Amlodipine Besilate and Indapamide. Amlodipine Besilate and Indapamide were estimated on C18 column using Acetonitrile: Water (contains 0.2% of Triethylamine and adjusting the pH to 4.0 with 10 % orthophosphoric acid) in a proportion of 70:30 v/v as mobile phase and detection was carried out at 238 nm. Results of Validation study and assay of all three methods were found to be satisfactory. The developed method were statistically compared using one way ANOVA which suggest that there is no significance difference among all three methods.

Biographie de l'auteur

Mehul M. Patel (M.Pharm., Pharmaceutical Chemistry)Professional SummaryAssistant Professor with Five years of experience.Specialty areas include Medicinal Chemistry, Analytical technology and Pharmaceutical Chemistry.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659256099
ISBN 13 
9783659256097
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
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