Articles liés à Bioadhesive Microspheres as Sustained Release Drug...

Bioadhesive Microspheres as Sustained Release Drug Delivery System: An approach to Controlled Release Dosage Form - Couverture souple

Ahmed, Maizbha Uddin; Mahmood, Sharif; Islam, Mohammad Safiqul

 
9783659263545: Bioadhesive Microspheres as Sustained Release Drug Delivery System: An approach to Controlled Release Dosage Form
Couverture souple
ISBN 10 : 3659263540 ISBN 13 : 9783659263545
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Mucoadhisive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of pectin was prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr’s index, hausner ratio, micro encapsulation efficiency, drug release characteristics, surface characteristics; compatibility studies mucoadhesive properties. Pectin is a polysaccharide with a variable molecular weight. In the presence of calcium ions, pectin forms a gel of calcium pectinatethat are more resistant to disruption in the gut than alginate gel. Researchers have formulated oral controlled release products of glipizide by various techniques. Dosage forms that are retained in the stomach would increase the absorption, improve drug efficiency and decrease dose requirements. Thus, an attempt is made in the present investigation to use chitosan as a mucoadhesive polymer and prepare microspheres. The microspheres will be characterized by in-vitro and iv-vivo tests and factorial design will be employed to optimize the variables.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Mucoadhisive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of pectin was prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr’s index, hausner ratio, micro encapsulation efficiency, drug release characteristics, surface characteristics; compatibility studies mucoadhesive properties. Pectin is a polysaccharide with a variable molecular weight. In the presence of calcium ions, pectin forms a gel of calcium pectinatethat are more resistant to disruption in the gut than alginate gel. Researchers have formulated oral controlled release products of glipizide by various techniques. Dosage forms that are retained in the stomach would increase the absorption, improve drug efficiency and decrease dose requirements. Thus, an attempt is made in the present investigation to use chitosan as a mucoadhesive polymer and prepare microspheres. The microspheres will be characterized by in-vitro and iv-vivo tests and factorial design will be employed to optimize the variables.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659263540
ISBN 13 
9783659263545
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
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