Telomerase Activity in Normal and Neoplastic Lymph Nodes in the Dog: Telomerase, the Enzyme that Provides Neoplastic Cells of Immortality could be a Potential Target to Defeat Cancer - Couverture souple

Valentini, Fabio

 
9783659268496: Telomerase Activity in Normal and Neoplastic Lymph Nodes in the Dog: Telomerase, the Enzyme that Provides Neoplastic Cells of Immortality could be a Potential Target to Defeat Cancer
Couverture souple
ISBN 10 : 3659268496 ISBN 13 : 9783659268496
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

One of the several differences between a normal and a neoplastic cell is that there is a physiological limit to the number of possible cell replications in the former, whereas it appears to be unlimited in the latter. For this reason, cancer cells are thought to undergo a phenomenon of immortalization. The chromosome extremities contain structurally defined elements called telomeres. In normal somatic cells, each mitotic cycle leads to a reduction of telomere length until a critical point is reached. Telomere erosion to this critical length presents a signal for the cell to arrest further divisions and to undergo cellular senescence or to activate apoptosis. Telomeres that avoid critical shortening could, theoretically, replicate endlessly, thereby immortalizing the cell. One mechanism to restore telomere length is the activation of a specific reverse transcriptase called telomerase. Up-regulation of the telomerase enzyme provides immortalizing capacity to neoplastic cells.

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Présentation de l'éditeur

One of the several differences between a normal and a neoplastic cell is that there is a physiological limit to the number of possible cell replications in the former, whereas it appears to be unlimited in the latter. For this reason, cancer cells are thought to undergo a phenomenon of immortalization. The chromosome extremities contain structurally defined elements called telomeres. In normal somatic cells, each mitotic cycle leads to a reduction of telomere length until a critical point is reached. Telomere erosion to this critical length presents a signal for the cell to arrest further divisions and to undergo cellular senescence or to activate apoptosis. Telomeres that avoid critical shortening could, theoretically, replicate endlessly, thereby immortalizing the cell. One mechanism to restore telomere length is the activation of a specific reverse transcriptase called telomerase. Up-regulation of the telomerase enzyme provides immortalizing capacity to neoplastic cells.

Biographie de l'auteur

Dr Valentini graduated at the University of Bologna (Italy) in 1999. One year later he moved to the University of Illinois pursuing a 2-year MS and clinical oncology internship. In 2010 he started his residency in medical oncology for the ECVIM (European College of Veterinary Internal Medicine). Author of several articles in peer-reviewed journals

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659268496
ISBN 13 
9783659268496
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
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