Formulation of Bilayered Floating Tablets of Atorvastatin and Niacin: Formulation and Evaluation of Bilayered Floating Tablets of Atorvastatin Calcium and Niacin - Couverture souple

Haripriya, Puthoori; Murthy, T.E.G.K.; Kaushik, Atul

 
9783659268595: Formulation of Bilayered Floating Tablets of Atorvastatin and Niacin: Formulation and Evaluation of Bilayered Floating Tablets of Atorvastatin Calcium and Niacin
Couverture souple
ISBN 10 : 3659268593 ISBN 13 : 9783659268595
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia.

Biographie de l'auteur

My interest to develop a dosage form by applying different formulation and process techniques according to drug properties gave the basis for the present research work. Thanks for Lord Ganesh, my parents,Laxman Murthy K & DR Reddy's Laboratories for their kind support.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659268593
ISBN 13 
9783659268595
Reliure
Broché
Nombre de pages
148
Coordonnées du fabricant
non disponible
Personne responsable
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