Articles liés à Homology Modeling of Dopamine Receptors and Docking...

Homology Modeling of Dopamine Receptors and Docking Study: Structure Based Drug Design - Couverture souple

Gupta, Manish K.; Singh, Gagandip; Kumar, Ankit

 
9783659277016: Homology Modeling of Dopamine Receptors and Docking Study: Structure Based Drug Design
Couverture souple
ISBN 10 : 3659277010 ISBN 13 : 9783659277016
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules.

Biographie de l'auteur

Manish K. Gupta (M. Pharm., Ph.D.) is working as an associate professor at Dept. of Pharma. Chemistry, ISF College of Pharmacy, Moga, India. His research interests include ligand and structure based drug design, high dimensional QSAR studies and theoretical aspects of drug design. He has published several research papers in peer-reviewed journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659277010
ISBN 13 
9783659277016
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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