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Guar Gum Based Micro capsules for Colon Targeting of Tinidazole: DOE Approach for Optimization of Entrapment Efficiency and Drug Release Charecteristics - Couverture souple

Rao, Vinay; Pooja, Nirmala

 
9783659278211: Guar Gum Based Micro capsules for Colon Targeting of Tinidazole: DOE Approach for Optimization of Entrapment Efficiency and Drug Release Charecteristics
Couverture souple
ISBN 10 : 3659278211 ISBN 13 : 9783659278211
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Colon targeted micro capsules of Tinidazole were prepared by using Guar gum as the drug targeting polymer. The emulsion polymerization technique for preparation of the micro capsules was optimized using full factorial DOE. It was identified that the HLB value of the surfactant mixture was critical for maximizing entrapment efficiency. The in vitro drug release studies in pH 1.2, pH 4.5, pH 6.8 and pH 7.2 buffers indicated no significant drug release at any of these media. However, in pH 6.8 and pH 7.2 buffer enriched with Alpha galactosidase and Galactomannase enzymes, the drug release is complete. This indicates that the delivery system is designed to target the drug release in the Colon region where the release shall be triggered by the microorganisms present in the colon and long intestine.

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Présentation de l'éditeur

Colon targeted micro capsules of Tinidazole were prepared by using Guar gum as the drug targeting polymer. The emulsion polymerization technique for preparation of the micro capsules was optimized using full factorial DOE. It was identified that the HLB value of the surfactant mixture was critical for maximizing entrapment efficiency. The in vitro drug release studies in pH 1.2, pH 4.5, pH 6.8 and pH 7.2 buffers indicated no significant drug release at any of these media. However, in pH 6.8 and pH 7.2 buffer enriched with Alpha galactosidase and Galactomannase enzymes, the drug release is complete. This indicates that the delivery system is designed to target the drug release in the Colon region where the release shall be triggered by the microorganisms present in the colon and long intestine.

Biographie de l'auteur

Vinay Umesh Rao is Managing Director at Institute of Pharmaceutical Sciences (IPS), Hyderabad. This institution is dedicated to research in the area of pharmaceutical technology. He has completed his PhD in 1995 and has worked in the area of dosage form development in various capacities. He is also a Professor at Osmania University, Hyderabad.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659278211
ISBN 13 
9783659278211
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
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