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Azole Derivatives as an Protein Tyrosin Kinase Inhibitors: Synthesis and Antiproliferative Evaluation of Imatinib analogs - Couverture souple

Agrawal, Yogesh; Agrawal, Mona

 
9783659282942: Azole Derivatives as an Protein Tyrosin Kinase Inhibitors: Synthesis and Antiproliferative Evaluation of Imatinib analogs
Couverture souple
ISBN 10 : 3659282944 ISBN 13 : 9783659282942
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

In the present book “The Azoles Derivatives as Potent Protein Tyrosine Kinase Inhibitor”, we provide an exhaustive literature regarding the Antiproliferative potential of Protein Tyrosine Kinase Inhibitors. Various analogous of imatinib were Designed and prepared by replacing the pyrimidine ring of imatinib with an azole nucleous like Imidazole, Benzimidazole and Benzthiazole. Imatinib an well reputed anti-cancer agent contain pyrimidine ring, composition of various biological enzymes and proteins of normal cell, as analogous of ATP inhibit the natural cell protein Kinase, hence responsible for non-specificity in activity with low selectivity and side effects. BMS-33197 an excellent Bcr-Abl kinase inhibitor contain an oxazole nucleolus responsible for its activity so various imatinib analogous were prepared isosterically.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

In the present book “The Azoles Derivatives as Potent Protein Tyrosine Kinase Inhibitor”, we provide an exhaustive literature regarding the Antiproliferative potential of Protein Tyrosine Kinase Inhibitors. Various analogous of imatinib were Designed and prepared by replacing the pyrimidine ring of imatinib with an azole nucleous like Imidazole, Benzimidazole and Benzthiazole. Imatinib an well reputed anti-cancer agent contain pyrimidine ring, composition of various biological enzymes and proteins of normal cell, as analogous of ATP inhibit the natural cell protein Kinase, hence responsible for non-specificity in activity with low selectivity and side effects. BMS-33197 an excellent Bcr-Abl kinase inhibitor contain an oxazole nucleolus responsible for its activity so various imatinib analogous were prepared isosterically.

Biographie de l'auteur

Yogesh P. Agrawal studied at School of Pharmaceutical Sciences,UTD, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India and obtained her Master’s degree in the field of Pharmaceutical Chemistry in 2007. Currently an Assistant Professor in Department of Pharmaceutical Chemistry, Government College of Pharmacy, Ratnagiri, Mumbai University, India

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659282944
ISBN 13 
9783659282942
Reliure
Broché
Nombre de pages
84
Coordonnées du fabricant
non disponible
Personne responsable
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