Coherent Anti-Stokes Raman Scattering (CARS) Microscopy for Bioimaging: A theoretical and experimental study of near-filed and far-field CARS microscopy for biomedical imaging - Couverture souple

Lin, Jian

 
9783659289132: Coherent Anti-Stokes Raman Scattering (CARS) Microscopy for Bioimaging: A theoretical and experimental study of near-filed and far-field CARS microscopy for biomedical imaging
Couverture souple
ISBN 10 : 3659289132 ISBN 13 : 9783659289132
Editeur : LAP Lambert Academic Publishing, 2012

Synopsis

Coherent anti-Stokes Raman scattering (CARS) microscopy is a nonlinear Raman imaging technique that has received great attention for biological and biomedical imaging due to its ability of real-time, nonperturbative chemical mapping of live unstained cells and tissue based on molecular vibrations. However, the strong nonresonant background reduces the image contrast and sensitivity of CARS imaging. Its spatial resolution is limited by light diffraction. This research has systematically studied the near-field (NF) effects of nanoparticle sizes, orientations, polarization of excitations on NF-CARS imaging using FDTD method, and has developed a radially polarized near-field tip-enhanced (TE) CARS system for high-resolution vibrational imaging and a unique annular-aperture detection scheme for suppressing the solvent background. The novel TE-CARS technique and the multimodal nonlinear optical microscopy imaging platform developed in this work have great potential to provide new insights into better understanding of morphological, biochemical and biomolecular changes associated with tissue and cell pathologic transformation at the tissue, cellular and molecular levels without labeling.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

Lin Jian is a research fellow at the Department of Bioengineering in National University of Singapore. He received his Ph.D. degree from National University of Singapore. His main research field is nonlinear optical microscopy for biomedical imaging.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659289132
ISBN 13 
9783659289132
Reliure
Broché
Nombre de pages
120
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne