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Asymmetric Membrane Capsule- An Osmotic Approach: Formulation and Evaluation of Asymmetric Membrane Capsule Osmotic Pump of Gliclazide - Couverture souple

Teraiya, Sandipkumar; Patel, Shrujal; Jayswal, Bhargav

 
9783659300899: Asymmetric Membrane Capsule- An Osmotic Approach: Formulation and Evaluation of Asymmetric Membrane Capsule Osmotic Pump of Gliclazide
Couverture souple
ISBN 10 : 3659300896 ISBN 13 : 9783659300899
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The aim of this study was to demonstrate that the asymmetric membrane capsule can be used to deliver a poorly water soluble drug with a pH sensitive solubility such as gliclazide. In order to obtain the desired delivery duration, the drug was solubilized with the use of a pH-controlling excipient. The capsule wall membrane was made by a phase inversion process, in which asymmetric membrane was formed on glass mold pins by dipping the mold pins into a coating solution containing a polymeric material followed by dipping into a quench solution. This study evaluates the influence of coating formulation that was cellulose acetate (CA), ethylcellulose (EC), and plasticizer (glycerin and PEG 600). Results show capsule that made by CA with glycerol and PEG 600, which appear in asymmetric structure and are able to release gliclazide(GLZ) in significant percentage.Based on the result, influence of core formulation variables, including D-mannitol, sodium bicarbonate and the added amount of SLS were examined on the release of GLZ. It was found that HPMC 15cp was suitable to be a thickening agent and both added amount of HPMC and SLS showed a comparable and profoundly positive effect.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The aim of this study was to demonstrate that the asymmetric membrane capsule can be used to deliver a poorly water soluble drug with a pH sensitive solubility such as gliclazide. In order to obtain the desired delivery duration, the drug was solubilized with the use of a pH-controlling excipient. The capsule wall membrane was made by a phase inversion process, in which asymmetric membrane was formed on glass mold pins by dipping the mold pins into a coating solution containing a polymeric material followed by dipping into a quench solution. This study evaluates the influence of coating formulation that was cellulose acetate (CA), ethylcellulose (EC), and plasticizer (glycerin and PEG 600). Results show capsule that made by CA with glycerol and PEG 600, which appear in asymmetric structure and are able to release gliclazide(GLZ) in significant percentage.Based on the result, influence of core formulation variables, including D-mannitol, sodium bicarbonate and the added amount of SLS were examined on the release of GLZ. It was found that HPMC 15cp was suitable to be a thickening agent and both added amount of HPMC and SLS showed a comparable and profoundly positive effect.

Biographie de l'auteur

Mr. Sandip R. Teraiya is a young dynamic researcher who has earned Degree of M.Pharm with specialization in Pharmaceutics from Gujarat Technological University(Ahmedabad,India). Researcher has extensive exposure in Novel drug delivery system and he has published several international & national research articles.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659300896
ISBN 13 
9783659300899
Reliure
Broché
Nombre de pages
156
Coordonnées du fabricant
non disponible
Personne responsable
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