Cell Fate Analysis of Embryonic Stem Cell Neuronal Differentiation: Molecular comparison between in vitro neuronal differentiation and in vivo brain development - Couverture souple

Salti, Ahmad

Couverture souple

ISBN 10 : 3659302481 ISBN 13 : 9783659302480

Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Embryonic stem (ES) cells are a powerful source for generating potentially unlimited numbers of specialized cells. An important progress has been made to differentiate pluripotent stem cells toward different cell populations, in particular toward neuronal populations owing to their potential use in neurodegenerative diseases. However, ES cell based approaches face a number of challenges that hindered their application in biology and regenerative medicine. This book, therefore, present studies addressing these challenges by establishing a large panel of neural markers and region specific transcription factors linked to embryonic brain development in vivo. These markers were used to monitor and compare the in vitro and in vivo ES cell differentiation toward telencephalic and mesencephalic phenotypes. These studies allow a further optimization of the human and mouse ES cell culture protocols in order to obtain specific neuronal population as a source for neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The book should be useful for neuroscientists, students, or anyone else interested in stem cells and regenerative medicine.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3659302481
• ISBN 13: 9783659302480
• Reliure: Broché
• Nombre de pages: 152
• Coordonnées du fabricant: non disponible
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