D.O.E. Based Optimization of Compression Coated Tablets: Design and Development of Controlled Release Tablets of Tramadol HCl based on Compression Coating Platform Technology - Couverture souple

Rao, Vinay; Y., Radha Krishna; L., Sai Koundinya

 
9783659302671: D.O.E. Based Optimization of Compression Coated Tablets: Design and Development of Controlled Release Tablets of Tramadol HCl based on Compression Coating Platform Technology
Couverture souple
ISBN 10 : 3659302678 ISBN 13 : 9783659302671
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Compression coating provides an unique platform for formulating modified release products in a way the dosage form can successfully be targeted to localize the release of the drug in any desired portion of the GIT without the additional step of film coating. The current work focuses on the development and optimization of modified release Tramadol Hydrochloride tablets using this platform. The innovator product (Ultram ER) is a reservoir based functional film coated tablet system. The disadvantages of this system are that the coating is solvent based and the % weight gain required is in the range of 35 to 47% w/w leading to inordinately long processing time. The aim of the present work was to develop a product with dissolution profile matching to Ultram ER using the compression coating technique. Also, the effect of the concentration and viscosity grades of combination of HPMC polymers on the release profile was studied in DOE environment. The results of the DOE provide an optimized range of the three polymers which could potentially give the targeted release profile for all drugs which have solubility profiles similar to Tramadol HCl.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Compression coating provides an unique platform for formulating modified release products in a way the dosage form can successfully be targeted to localize the release of the drug in any desired portion of the GIT without the additional step of film coating. The current work focuses on the development and optimization of modified release Tramadol Hydrochloride tablets using this platform. The innovator product (Ultram ER) is a reservoir based functional film coated tablet system. The disadvantages of this system are that the coating is solvent based and the % weight gain required is in the range of 35 to 47% w/w leading to inordinately long processing time. The aim of the present work was to develop a product with dissolution profile matching to Ultram ER using the compression coating technique. Also, the effect of the concentration and viscosity grades of combination of HPMC polymers on the release profile was studied in DOE environment. The results of the DOE provide an optimized range of the three polymers which could potentially give the targeted release profile for all drugs which have solubility profiles similar to Tramadol HCl.

Biographie de l'auteur

Vinay U. Rao is Managing Director at Institute of Pharmaceutical Sciences (IPS, Hyderabad). IPS is dedicated to research in the area of Pharmaceutical Technology. He has completed his PhD in 1995 and has worked in the area of dosage form design in various capacities. Presently he is working as Professor of Pharmaceutics at Osmania University.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3659302678
ISBN 13 
9783659302671
Reliure
Broché
Nombre de pages
124
Coordonnées du fabricant
non disponible
Personne responsable
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