Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer - Couverture souple

Jambukiya, Vipul; Parmar, Ramesh; Sheth, N. R.

 
9783659337536: Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer
Couverture souple
ISBN 10 : 3659337536 ISBN 13 : 9783659337536
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU

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Présentation de l'éditeur

Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU

Biographie de l'auteur

Vipul V. Jambukiya currently i am working as drug inspector at junagdha, gujarat. i did my M Pharma in Department of pharmaceutics, Saurashtra University. currently i am doing Ph. D. from Saurashtra University Under the Guidance of Dr. J. K. Patel.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659337536
ISBN 13 
9783659337536
Reliure
Broché
Nombre de pages
92
Coordonnées du fabricant
non disponible
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