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Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends - Couverture souple

Chapla, Nikunj; Chapla, Vishal; Pujara, Naisarg

 
9783659346040: Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends
Couverture souple
ISBN 10 : 3659346047 ISBN 13 : 9783659346040
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is fast dissolving tablets (FDT) of Phenylephrine Hydrochloride, a selective α1 adrenergic receptor antagonist, used for nasal decongestant and producing mydriasis effect. In present work an attempt has been made by formulating fast dissolving tablets of Phenylephrine Hydrochloride by superdisintegrants addition method using croscarmellose sodium, crospovidone and sodium starch glycolate. A total of 10 batches were prepared by using various combination and concentration of superdisintegrants and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release studies, kinetic studies and stability studies. Amongst all the formulations F2 and F9 were found to be better formulations which include single superdisintegrants and combination of superdisintegrants. Finally it was concluded that FDT of Phenylephrine Hydrochloride will be used as a novel drug dosage form for pediatrics and geriatrics.

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À propos de l'auteur

Nikunj Chapla, completed Master of Pharmacy, Pharmaceutics from Department of Pharmaceutics, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences Deralakatte, Mangalore at NITTE University.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659346047
ISBN 13 
9783659346040
Reliure
Broché
Nombre de pages
148
Coordonnées du fabricant
non disponible
Personne responsable
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