Formulation Of Methylprednisolone Colon Targeted Tablets - Couverture souple

Kumar, Vasanth; Kumar, Sateesh; Kumar, Vijaya

 
9783659348686: Formulation Of Methylprednisolone Colon Targeted Tablets
Couverture souple
ISBN 10 : 3659348686 ISBN 13 : 9783659348686
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

The intent of current investigation is to make colon targeting methylprednisolone compression coated tablets using time dependent polymer hydroxypropyl methylcellulose and pH sensitive polymer Eudragit S100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The prepared formulations were optimized using dissolution tests and evaluated for colonic delivery by x-ray imaging and pharmacokinetic studies in healthy humans. The optimized formulation of methylprednisolone showed 10.52±0.68% in the initial lag period of 5 h followed by progressive release up to 101.43±3.33% for 24 h. The x-ray imaging study in human volunteers illustrated that the tablets arrived to colon with no loss of integrity in the upper gastrointestinal tract. Cmax of colon targeted compression coated tablets was 10324.83 ng/ml at Tmax 10 h which clearly indicates the capability of compression coated tablets to give colon targeting.

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Présentation de l'éditeur

The intent of current investigation is to make colon targeting methylprednisolone compression coated tablets using time dependent polymer hydroxypropyl methylcellulose and pH sensitive polymer Eudragit S100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The prepared formulations were optimized using dissolution tests and evaluated for colonic delivery by x-ray imaging and pharmacokinetic studies in healthy humans. The optimized formulation of methylprednisolone showed 10.52±0.68% in the initial lag period of 5 h followed by progressive release up to 101.43±3.33% for 24 h. The x-ray imaging study in human volunteers illustrated that the tablets arrived to colon with no loss of integrity in the upper gastrointestinal tract. Cmax of colon targeted compression coated tablets was 10324.83 ng/ml at Tmax 10 h which clearly indicates the capability of compression coated tablets to give colon targeting.

Biographie de l'auteur

Vasanth Kumar is a post graduate student doing his Master of pharmacy in Pharmaceutical at Jangaon Institute of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh. After completing his graduation in the year 2012,he has working as a SAS Programmer in Life Sciences Pvt. Ltd. HYD.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659348686
ISBN 13 
9783659348686
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
Personne responsable
non disponible