Articles liés à Anti Hypertensive drug- Formulation and its characterization

Anti Hypertensive drug- Formulation and its characterization - Couverture souple

Patel, Ravi; Bhangale, Jitendra

 
9783659355202: Anti Hypertensive drug- Formulation and its characterization
Couverture souple
ISBN 10 : 3659355208 ISBN 13 : 9783659355202
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Conventional oral dosage forms provide a specific drug concentration in the systemic circulation without offering any control over the rate of drug delivery. Controlled-release drug delivery systems (CRDDS) provide drug release at a predetermined, predictable, and controlled rate. It was attempt to develop a gastro retentive drug delivery system of anti hypertensive drug using different polymers like that HPMCK4M, Xanthangum, PolyoxWSR303as matrixing agent, swelling agent, respectivel. A simplex lattice design was applied to combined effect of three formulation variables (ie, amount of HPMCK4M (X1), xanthangum (X2), and PolyoxWSR303 (X3). Results of multiple regression analysis indicated that low level of X1 and X 2 and high level of X3 should be used to manufacture the tablet formulation with desired in % swelling index and % drug release profile . When Polyox 303 was used, % swelling index increased, with increase on the total amount of drug released. Decreasing the amount of HPMC K4M while maintaining the total amount of polymer constant increased the release rate and total amount released. Decreasing the total amount of polymer decreases the swelling and work of penetration,

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Conventional oral dosage forms provide a specific drug concentration in the systemic circulation without offering any control over the rate of drug delivery. Controlled-release drug delivery systems (CRDDS) provide drug release at a predetermined, predictable, and controlled rate. It was attempt to develop a gastro retentive drug delivery system of anti hypertensive drug using different polymers like that HPMCK4M, Xanthangum, PolyoxWSR303as matrixing agent, swelling agent, respectivel. A simplex lattice design was applied to combined effect of three formulation variables (ie, amount of HPMCK4M (X1), xanthangum (X2), and PolyoxWSR303 (X3). Results of multiple regression analysis indicated that low level of X1 and X 2 and high level of X3 should be used to manufacture the tablet formulation with desired in % swelling index and % drug release profile . When Polyox 303 was used, % swelling index increased, with increase on the total amount of drug released. Decreasing the amount of HPMC K4M while maintaining the total amount of polymer constant increased the release rate and total amount released. Decreasing the total amount of polymer decreases the swelling and work of penetration,

Biographie de l'auteur

Prof. Ravi Patel is working as head and Assistant Professor, Dept of Pharmaceutics and Prof. Jitendra Bhangale is working as head and Assistant Professor, Dept of Pharmacology at Shree Saurashtra Patel Sewa Samaj's Smt. N. M. Padalia Pharmacy College, Ahmedabad, Gujarat, 382210 India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659355208
ISBN 13 
9783659355202
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
Personne responsable
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