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Development of Osmotically Controlled Drug Delivery System: Development and In-Vitro evaluation of Elementary Osmotic Pump (Tablet) of Etoricoxib - Couverture souple

Shekh, Tabasubano; Bhople, Amit; Jaiswal, Sunil

 
9783659370519: Development of Osmotically Controlled Drug Delivery System: Development and In-Vitro evaluation of Elementary Osmotic Pump (Tablet) of Etoricoxib
Couverture souple
ISBN 10 : 3659370517 ISBN 13 : 9783659370519
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Etoricoxib is non steroidal anti-inflammatory drug specifically Cyclooxygenase 2 (COX-2) enzyme inhibitor. Etoricoxib have serious side effect like gastric disturbance, gastric ulceration, gastrointestinal (GIT) bleeding. Conventional drug delivery systems do not have much control over the drug release and effective concentration of drug reach at the target site. It may lead to unsteady plasma drug level result into adverse effect due to plasma drug level crossing therapeutic window and undertherparutic response because of plasma drug level below therapeutic window. GIT side effect of Etoricoxib due to unsteady plasma drug level when administered in conventional dosage form. Development of elementary osmotic pump for etoricoxib release the drug in controlled fashion by zero order result in mentainance of constant plasma drug level for long period of time lead to diminished serious GIT side effect of etoricoxib.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Etoricoxib is non steroidal anti-inflammatory drug specifically Cyclooxygenase 2 (COX-2) enzyme inhibitor. Etoricoxib have serious side effect like gastric disturbance, gastric ulceration, gastrointestinal (GIT) bleeding. Conventional drug delivery systems do not have much control over the drug release and effective concentration of drug reach at the target site. It may lead to unsteady plasma drug level result into adverse effect due to plasma drug level crossing therapeutic window and undertherparutic response because of plasma drug level below therapeutic window. GIT side effect of Etoricoxib due to unsteady plasma drug level when administered in conventional dosage form. Development of elementary osmotic pump for etoricoxib release the drug in controlled fashion by zero order result in mentainance of constant plasma drug level for long period of time lead to diminished serious GIT side effect of etoricoxib.

Biographie de l'auteur

Ms. Tabasubano Shekh has obtained her graduation in Pharmacy i.e. B.Pharm. Her main area of research are Novel Drug Delivery System in particular the Osmotically Controlled Drug Delivery System. She has Industrial experience in Drug Regulatory Affaires Department. She Published number of research and review papers in various journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659370517
ISBN 13 
9783659370519
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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