In the process of pursuing the objective of vaginal drug delivery system, Our work was aimed on in-vitro-in-vivo correlation of Zidovudine loaded particulated vaginal bioadhesive tablet.The graphical analysis confirms, a good degree of correlation. Fulfilling our objective. A good correlation was observed between the release rate constant and AUC of the formulation also between the mean dissolution time and mean residence time of the designed formulation epitomized. Degree A level of correlation was established from the results. Thus, the formulation has the potential to liberate Zidovudine following Fickian diffusion mechanism having a good degree of in-vitro- in-vivo correlation.
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In the process of pursuing the objective of vaginal drug delivery system, Our work was aimed on in-vitro-in-vivo correlation of Zidovudine loaded particulated vaginal bioadhesive tablet.The graphical analysis confirms, a good degree of correlation. Fulfilling our objective. A good correlation was observed between the release rate constant and AUC of the formulation also between the mean dissolution time and mean residence time of the designed formulation epitomized. Degree A level of correlation was established from the results. Thus, the formulation has the potential to liberate Zidovudine following Fickian diffusion mechanism having a good degree of in-vitro- in-vivo correlation.
Dr. Arkendu Chatterjee, presently the Head of the Departments of Industrial Pharmacy of Nalanda College of Pharmacy, having Eight years of teaching experience and he did his Ph.D. from University of North Bengal, West Bengal, India. He had 14 research papers in national & 2 research papers in international journal and two books had published.
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