Enhancement of Solubility & Dissolution Rate by Co-Crystal Technology - Couverture souple

Ubaidulla, Udhumansha; M.P., Vijaya Kumar

 
9783659379796: Enhancement of Solubility & Dissolution Rate by Co-Crystal Technology
Couverture souple
ISBN 10 : 3659379794 ISBN 13 : 9783659379796
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Acyclovir conventional tablets have been used for long period for the treatment of viral infections. When orally administered, it is showing slow and incomplete absorption from gastrointestinal tract. The total oral bioavailability of acyclovir is between 15–30% due to poorly soluble drug and short plasma half life (3 Hrs). Oral bioavailability of acyclovir can be achieved by improving the solubility and dissolution rate. Several techniques have been used to improve the solubility and dissolution rate of acyclovir such as solid dispersions and spherical agglomerates and complexes. Co- crystals recently been used for improving oral solubility and dissolution rate of the drugs. The present investigation of the work is to prepare acyclovir co-crystals with chitosan by using solvent change method to improve the solubility and dissolution rate of acyclovir. The second objective of this work is to extent the maximum bioavailability of acyclovir by retaining the drug in gastric region for longer time. To achieve this goal, the prepared co-crystal is made to float in the gastric region by using sodium alginate as non-effervescent floating technique.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Acyclovir conventional tablets have been used for long period for the treatment of viral infections. When orally administered, it is showing slow and incomplete absorption from gastrointestinal tract. The total oral bioavailability of acyclovir is between 15–30% due to poorly soluble drug and short plasma half life (3 Hrs). Oral bioavailability of acyclovir can be achieved by improving the solubility and dissolution rate. Several techniques have been used to improve the solubility and dissolution rate of acyclovir such as solid dispersions and spherical agglomerates and complexes. Co- crystals recently been used for improving oral solubility and dissolution rate of the drugs. The present investigation of the work is to prepare acyclovir co-crystals with chitosan by using solvent change method to improve the solubility and dissolution rate of acyclovir. The second objective of this work is to extent the maximum bioavailability of acyclovir by retaining the drug in gastric region for longer time. To achieve this goal, the prepared co-crystal is made to float in the gastric region by using sodium alginate as non-effervescent floating technique.

Biographie de l'auteur

Dr. U. Ubaidulla M.Pharm., Ph.D., is a Professor at the Dept. of Pharmaceutics, C.L. Baid Metha College of Pharmacy, The TN Dr. MGR Medical University, Chennai, India. He is also handling various funded projects like Nanoparticles, Microspheres, Pelletization, Transdermal, Liposomes etc.,

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659379794
ISBN 13 
9783659379796
Reliure
Broché
Nombre de pages
88
Coordonnées du fabricant
non disponible
Personne responsable
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