Formulation of Self Nano-Emulsifying Systems of Ezetimibe: Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies - Couverture souple

Bandyopadhyay, Shantanu; Singh, Bhupinder; Katare, O.P.

 
9783659404696: Formulation of Self Nano-Emulsifying Systems of Ezetimibe: Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies
Couverture souple
ISBN 10 : 3659404691 ISBN 13 : 9783659404696
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. However, the focus has recently shifted to lipid-based formulations owing to their ability to improve the oral bioavailability of poorly water soluble drug compounds. In this regard, self-emulsifying drug delivery systems (SEDDS), particularly nano-based systems, have been able to surmount the above mentioned problems. SEDDS are the recent technological innovations which are physically more stable and easier to manufacture with the globule size ranging between 10 to 1000 nm. Not only this, SEDDS are able to modulate the drug absorption leading ultimately to enhance oral bioavailability.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. However, the focus has recently shifted to lipid-based formulations owing to their ability to improve the oral bioavailability of poorly water soluble drug compounds. In this regard, self-emulsifying drug delivery systems (SEDDS), particularly nano-based systems, have been able to surmount the above mentioned problems. SEDDS are the recent technological innovations which are physically more stable and easier to manufacture with the globule size ranging between 10 to 1000 nm. Not only this, SEDDS are able to modulate the drug absorption leading ultimately to enhance oral bioavailability.

Biographie de l'auteur

Shantanu Bandyopadhyay, M.Pharm, has recently submitted his doctoral research to Panjab University, Chandigarh, India. He has contributed in 13 research and review publications, 1 book review, 4 book chapters and 36 poster presentations. He is currently member of editorial board of one journal and on the reviewer’s panel of 2 journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659404691
ISBN 13 
9783659404696
Reliure
Broché
Nombre de pages
156
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne