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Design and Development of Carvedilol Phosphate Floating Microsphere: Formulation and in-vitro Evalution of Carvedilol Phosphate Floating Microsphere - Couverture souple

Joshi, Pranav; Patel, Mukesh; Patel, Natavarlal

 
9783659407635: Design and Development of Carvedilol Phosphate Floating Microsphere: Formulation and in-vitro Evalution of Carvedilol Phosphate Floating Microsphere
Couverture souple
ISBN 10 : 3659407631 ISBN 13 : 9783659407635
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Carvedilol has unique pharmacological profile. It blocks β1, β2, and α1 receptors, used in the management of hypertension and as an adjunct to standard therapy in symptomatic heart failure and also produces vasodilation. In the present study, an attempt has been made to improve drug concentration in the stomach by preparing gastroretentive floating microsphere of carvedilol phosphate to maintain drug levels within a desired range, reduce dosing frequency, Improve patient compliance, improve dissolution and at the site of absorption.Drug molecules presenting no difficulties in their solubility and/or absorption problems are good candidates for oral controlled release formulations but Obstacle may arise for many drugs related to their solubility and/or absorption that may be overcome by formulating Gastroretentive systems which prolong the gastric retention time, improves solubility and hence improves bioavailability for drugs that are less soluble in a high pH environment.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Carvedilol has unique pharmacological profile. It blocks β1, β2, and α1 receptors, used in the management of hypertension and as an adjunct to standard therapy in symptomatic heart failure and also produces vasodilation. In the present study, an attempt has been made to improve drug concentration in the stomach by preparing gastroretentive floating microsphere of carvedilol phosphate to maintain drug levels within a desired range, reduce dosing frequency, Improve patient compliance, improve dissolution and at the site of absorption.Drug molecules presenting no difficulties in their solubility and/or absorption problems are good candidates for oral controlled release formulations but Obstacle may arise for many drugs related to their solubility and/or absorption that may be overcome by formulating Gastroretentive systems which prolong the gastric retention time, improves solubility and hence improves bioavailability for drugs that are less soluble in a high pH environment.

Biographie de l'auteur

Mr. Pranav Joshi have completed B.Pharma from Rajiv Gandhi University of health sciences, Bangalore and awarded gold medal for being topper of college.He completed M.pharma from Gujarat Technological university, Ahmadabad, also he has published many research paper in international journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659407631
ISBN 13 
9783659407635
Reliure
Broché
Nombre de pages
144
Coordonnées du fabricant
non disponible
Personne responsable
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