Study of BMP-2 and stromal cell derived factor-1 in prostate cancer - Couverture souple

Fata, Azadeh

 
9783659407772: Study of BMP-2 and stromal cell derived factor-1 in prostate cancer
Couverture souple
ISBN 10 : 3659407771 ISBN 13 : 9783659407772
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

It was reported earlier that the exogenous BMP-2 treatment of two different primary fibroblastic cultures, each derived from a primary prostate tumor of the Pten null mouse model, results in enhanced secretion of SDF-1, a chemokine that functions as both chemoattractant for cell migration and mitogen for cell proliferation and survival. In the current study, we expanded the primary tumor or AD tumor CAF cultures by five more in number to determine how consistent the observed effect of BMP-2 is. While there is indeed a consistent enhancement of SDF-1 induction in all AD-CAF cultures, the degree of induction appears to vary widely. It is noteworthy that the single CRPC-CAF that we tested, however, appears to be distinct from the AD-CAFs in regard to two parameters. First, the CRPC-CAFs are found in repeated experiments, to naturally secrete a strong level of SDF-1, 4-fold higher than the best level seen in the AD-CAFs. Second, the induction of SDF-1 by BMP-2 is similarly increased in the CRPC CAFs. Thus it appears that the biological effect induced by BMP-2 is cell type dependent.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

It was reported earlier that the exogenous BMP-2 treatment of two different primary fibroblastic cultures, each derived from a primary prostate tumor of the Pten null mouse model, results in enhanced secretion of SDF-1, a chemokine that functions as both chemoattractant for cell migration and mitogen for cell proliferation and survival. In the current study, we expanded the primary tumor or AD tumor CAF cultures by five more in number to determine how consistent the observed effect of BMP-2 is. While there is indeed a consistent enhancement of SDF-1 induction in all AD-CAF cultures, the degree of induction appears to vary widely. It is noteworthy that the single CRPC-CAF that we tested, however, appears to be distinct from the AD-CAFs in regard to two parameters. First, the CRPC-CAFs are found in repeated experiments, to naturally secrete a strong level of SDF-1, 4-fold higher than the best level seen in the AD-CAFs. Second, the induction of SDF-1 by BMP-2 is similarly increased in the CRPC CAFs. Thus it appears that the biological effect induced by BMP-2 is cell type dependent.

Biographie de l'auteur

I have a B.S. degree in Bioengineering. After graduating from UC Berkeley I was happy to follow my dream of becoming a research assistant and work in academia. Now I'm submitting my Masters Degree Thesis proudly after a hard work and dedication that I had all throughout my life.Best Wishes,Azadeh Fata

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659407771
ISBN 13 
9783659407772
Reliure
Broché
Nombre de pages
52
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne