Pharmaceutical Drug Analysis by Atomic Absorption Spectroscopy: Basics, Concepts, & Methods - Couverture souple

Jawla, Sunil

Couverture souple

ISBN 10 : 3659409057 ISBN 13 : 9783659409059

Editeur : LAP Lambert Academic Publishing, 2013

Synopsis

Naproxen and ibuprofen (aryl propionic acid derivatives) both are classified as non-steroidal anti-inflammatory agents. Except HPLC, no sensitive methods were reported for both the drugs. HPLC methods suffer from two drawbacks- first; requirement of costly chemicals and second; more time consuming. Because atomic absorption spectroscopy (AAS) methods are simple, sensitive, rapid, reproducible and uses low cost chemicals. The objective of present research work was to develop highly sensitive and economical analytical methods for the quantitative estimation of naproxen and ibuprofen in pharmaceutical formulations by AAS. The methods were based on the reaction of naproxen and ibuprofen with copper and cobalt chloride to form coloured metal complexes. These complexes were extracted with organic solvents and digested with acids. Naproxen and ibuprofen were indirectly estimated by AAS via the determination of the copper and cobalt content in the formed complexes. The proposed methods may be used for routine analysis of pharmaceutical formulations containing aryl propionic acid derivatives and similar pharmaceutical drugs by the analytical chemist.

A propos du livre

À propos de l?auteur

Mr. Sunil Jawla (M. Pharm, GATE) is currently working as Assistant Professor (Pharmaceutical Chemistry) at ITS Paramedical College (Pharmacy), Ghaziabad, India. He has more than 9 years of teaching and research experience. His research interests are isolation of antidiabetic leads from naturals, molecular modelling & analytical method developments.

Détails de l'édition

• Éditeur: LAP Lambert Academic Publishing
• Date d'édition: 2013
• Langue: anglais
• ISBN 10: 3659409057
• ISBN 13: 9783659409059
• Reliure: Broché
• Nombre de pages: 96
• Coordonnées du fabricant: non disponible
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