Formulation, Development & Evaluation of Multi-compartment Dosage Form: For Immediate Relief From Hypertension - Couverture souple

Pujara, Naisarg; Parmar, Ramesh

 
9783659410475: Formulation, Development & Evaluation of Multi-compartment Dosage Form: For Immediate Relief From Hypertension
Couverture souple
ISBN 10 : 3659410470 ISBN 13 : 9783659410475
Editeur : LAP Lambert Academic Publishing, 2013

Synopsis

In the present study, formulation of multi-compartment dosage form containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance in case of hypertension. Triple combination of antihypertensive drugs induces superior reduction in blood pressure as compared to conventional dosage form. The basic aim of this work is to produce immediate release action of drug from the hard gelatin capsule containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide. Soft gelatin capsule was prepared by encapsulation method using propylene glycol and PEG 400 as solubilizing agents. The granules were prepared by wet granulation method using PVP K30 as binder. The fast disintegrating tablets were prepared by direct compression method using croscarmellose sodium and crospovidone as super disintegrating agents. Multi-compartment dosage form was considered as optimized formulation for immediate release of antihypertensive drugs.

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À propos de l?auteur

Naisarg D. Pujara, Master of Pharmacy, Pharmaceutics at Gujarat Technological University. Pharmacy Scholar at S. J. Thakkar Pharmacy College, Rajkot, Gujarat, India. Published Five International Books, Seven National & International Research articles and Five National & International Review articles. Reviewer of Two Elsevier Journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659410470
ISBN 13 
9783659410475
Reliure
Broché
Nombre de pages
188
Coordonnées du fabricant
non disponible
Personne responsable
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