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Mixed Solvency Concept: A Easy method to enhance the solubility & bioavailability of drugs - Couverture souple

Mansuk, Avinash; Narkhede, Kantilal; Harish, Lukkad

 
9783659414954: Mixed Solvency Concept: A Easy method to enhance the solubility & bioavailability of drugs
Couverture souple
ISBN 10 : 3659414956 ISBN 13 : 9783659414954
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

In these investigation conventional piroxicam capsule has slow onset of action (45-60 min) and poor bioavailability (50-60%), and therefore cannot be given in emergency clinical situations like postoperative pain, rheumatoid arthritis or osteoarthritis. So purpose of research was to provide a fast dissolving dosage form of piroxicam, which can provide quick onset of action by using mixed solvency concept. First carried out Initially solubility of piroxicam was determined individually in 3 hydrotropic agents like sodium benzoate, sodium citrate, niacinamide and 4 water soluble polymer namely HPBCD, PVP K30, PEG400, PEG8000 at conc. of 40% w/v solutions using purified water as solvent. Highest solubility was obtained in 40% sodium benzoate solution. Then different combinations of 2, 3 and 4 hydrotropic agents+water soluble polymer in different ratios were used to determine solubility, so that total conc. of solubilizer blend was always 40%. Highest solubility was obtained in solution of sodium benzoate+HP-BCD+PVP K30 at optimum ratio of 15:15:10. This optimized combination was utilized in preparing solid dispersions having enhanced solubility & used for pharmaceutical formulations.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

In these investigation conventional piroxicam capsule has slow onset of action (45-60 min) and poor bioavailability (50-60%), and therefore cannot be given in emergency clinical situations like postoperative pain, rheumatoid arthritis or osteoarthritis. So purpose of research was to provide a fast dissolving dosage form of piroxicam, which can provide quick onset of action by using mixed solvency concept. First carried out Initially solubility of piroxicam was determined individually in 3 hydrotropic agents like sodium benzoate, sodium citrate, niacinamide and 4 water soluble polymer namely HPBCD, PVP K30, PEG400, PEG8000 at conc. of 40% w/v solutions using purified water as solvent. Highest solubility was obtained in 40% sodium benzoate solution. Then different combinations of 2, 3 and 4 hydrotropic agents+water soluble polymer in different ratios were used to determine solubility, so that total conc. of solubilizer blend was always 40%. Highest solubility was obtained in solution of sodium benzoate+HP-BCD+PVP K30 at optimum ratio of 15:15:10. This optimized combination was utilized in preparing solid dispersions having enhanced solubility & used for pharmaceutical formulations.

Biographie de l'auteur

Mr. Avinash G. Mansuk, completed his M.pharmacy in Pharmaceutics from university of pune. Author has participated in several national and international conference. Author has several national & international publications. Author have experience of teaching in reputed pharmacy college.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659414956
ISBN 13 
9783659414954
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
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