Articles liés à Protective effect of D-Pinitol against breast cancer:...

Protective effect of D-Pinitol against breast cancer: D-Pinitol inhibits breast cancer: An in-vitro and in-vivo approach - Couverture souple

Rengarajan, Thamaraiselvan; Nandakumar, Natarajan; Balasubramanian, M.P.

 
9783659416934: Protective effect of D-Pinitol against breast cancer: D-Pinitol inhibits breast cancer: An in-vitro and in-vivo approach
Couverture souple
ISBN 10 : 3659416932 ISBN 13 : 9783659416934
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

This book describes the protective efficacy of D-Pinitol against experimental mammary carcinoma and in human breast cancer cell lines(MCF-7&MDA-MB-231).Breast cancer is the most common cancer in women. Great efforts have been made in the treatment of breast cancer.D-Pinitol found in large quantities about 1% in dry weight of soybean meal and in soy foods. The present study shows that D-Pinitol induced apoptosis in MCF-7&MDA-MB-231 cells. The objective of the study was to evaluate the players of apoptotic cascade, tumor suppressor protein expressions in the presence of D-Pinitol in human breast cancer cells. Several proteins involved in this process were probed using appropriate antibodies, the intracellular redox levels and the viability of cells were analyzed in control and D-Pinitol treated cells. The mechanism of D-Pinitol mediated apoptosis was determined. Anticancer property of D-Pinitol in an animal model of mammary carcinoma was also explored. D-Pinitol exhibits excellent therapeutic activity. The implication of this inter-disciplinary approach will be useful in cancer detection, diagnosis, treatment with drugs, and for follow-up during chemotherapy.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book describes the protective efficacy of D-Pinitol against experimental mammary carcinoma and in human breast cancer cell lines(MCF-7&MDA-MB-231).Breast cancer is the most common cancer in women. Great efforts have been made in the treatment of breast cancer.D-Pinitol found in large quantities about 1% in dry weight of soybean meal and in soy foods. The present study shows that D-Pinitol induced apoptosis in MCF-7&MDA-MB-231 cells. The objective of the study was to evaluate the players of apoptotic cascade, tumor suppressor protein expressions in the presence of D-Pinitol in human breast cancer cells. Several proteins involved in this process were probed using appropriate antibodies, the intracellular redox levels and the viability of cells were analyzed in control and D-Pinitol treated cells. The mechanism of D-Pinitol mediated apoptosis was determined. Anticancer property of D-Pinitol in an animal model of mammary carcinoma was also explored. D-Pinitol exhibits excellent therapeutic activity. The implication of this inter-disciplinary approach will be useful in cancer detection, diagnosis, treatment with drugs, and for follow-up during chemotherapy.

Biographie de l'auteur

Mr.T.Rengarajan obtained his PhD degree inPharmacology and Environmental Toxicology in 2013from the University of Madras. Since then he isactively involved in the research activities related to areas of Cancer Biology. He is the author of several articles published in reputed journals and presented several papers in leading conferences.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659416932
ISBN 13 
9783659416934
Reliure
Broché
Nombre de pages
284
Coordonnées du fabricant
non disponible
Personne responsable
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