Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form: Analytical Method Development & Validation - Couverture souple

Patel, Ravi B.; Badmanaban, R.; Dave, J. B.

9783659425288: Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form: Analytical Method Development & Validation

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ISBN 10 : 3659425281 ISBN 13 : 9783659425288

Editeur : LAP Lambert Academic Publishing, 2013

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A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 �g/mL and 10-60 �g/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method.

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� propos de l?auteur

M.Pharm(Quality Assurance) ,Shri Sarvajanik Pharmacy College, Mehsana affiliated to Gujarat Technological University, Ahmedabad.

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�diteur: LAP Lambert Academic Publishing
Date d'�dition: 2013
Langue: anglais
ISBN 10: 3659425281
ISBN 13: 9783659425288
Reliure: Broch�
Nombre de pages: 84
Coordonn�es du fabricant: non disponible
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Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form

Ravi B. Patel

Edit� par LAP LAMBERT Academic Publishing Jul 2013, 2013

ISBN 10 : 3659425281 ISBN 13 : 9783659425288

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 �g/mL and 10-60 �g/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method. 84 pp. Englisch. N� de r�f. du vendeur 9783659425288

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Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form

Patel, Ravi B.; Badmanaban, R.; Dave, J. B.

Edit� par VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2013

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Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form

Patel, Ravi B.; Badmanaban, R.; Dave, J. B.

Edit� par VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2013

ISBN 10 : 3659425281 ISBN 13 : 9783659425288

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Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form

Patel, Ravi B.; Badmanaban, R.; Dave, J. B.

Edit� par VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2013

ISBN 10 : 3659425281 ISBN 13 : 9783659425288

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Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form

Ravi B. Patel|R. Badmanaban|J. B. Dave

Edit� par LAP LAMBERT Academic Publishing, 2013

ISBN 10 : 3659425281 ISBN 13 : 9783659425288

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Patel Ravi B.M.Pharm(Quality Assurance) ,Shri Sarvajanik Pharmacy College, Mehsana affiliated to Gujarat Technological University, Ahmedabad.A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form. N� de r�f. du vendeur 158078076

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Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form

Ravi B. Patel

Edit� par LAP LAMBERT Academic Publishing Jul 2013, 2013

ISBN 10 : 3659425281 ISBN 13 : 9783659425288

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 �g/mL and 10-60 �g/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 84 pp. Englisch. N� de r�f. du vendeur 9783659425288

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Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form : Analytical Method Development & Validation

Ravi B. Patel

Edit� par LAP LAMBERT Academic Publishing, 2013

ISBN 10 : 3659425281 ISBN 13 : 9783659425288

Neuf Taschenbuch

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Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 �g/mL and 10-60 �g/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method. N� de r�f. du vendeur 9783659425288

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