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SNEDDS for improved oral Bioavailability of BCS classII drug-IVIVC: Self nanoemulsifying drug delivery system of poorly soluble drug Olnzapine for enhanced oral bioavailability and IVIVC - Couverture souple

Sureshkumar, Raman; Ganesh, Gonnan Nandhi Krishnan

 
9783659440489: SNEDDS for improved oral Bioavailability of BCS classII drug-IVIVC: Self nanoemulsifying drug delivery system of poorly soluble drug Olnzapine for enhanced oral bioavailability and IVIVC
Couverture souple
ISBN 10 : 3659440485 ISBN 13 : 9783659440489
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Modern drug discovery technique led to the consistent increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble. A great challenge facing the pharmaceutical scientist is making these molecules into orally administered medications with sufficient bioavailability. One of the most popular approaches to improve the oral bioavailability of these molecules is the utilization of a lipid based drug delivery system. Development and optimization of formulation is an integral part of manufacturing and marketing of any therapeutic agent which is indeed a time consuming and costly process. Optimization process may require alteration in formulation composition, manufacturing process, equipment and batch sizes. If these types of changes are applied to a formulation, studies in human healthy volunteers may be required to prove that the new formulation is bioequivalent with the old one.IVIVC includes in vivo relevance to in vitro dissolution specifications and can serve as surrogate for in vivo bioavailability and to support biowaivers. This book provides the information about the use of biorelevant media as media an alternative for in vivo studies.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Modern drug discovery technique led to the consistent increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble. A great challenge facing the pharmaceutical scientist is making these molecules into orally administered medications with sufficient bioavailability. One of the most popular approaches to improve the oral bioavailability of these molecules is the utilization of a lipid based drug delivery system. Development and optimization of formulation is an integral part of manufacturing and marketing of any therapeutic agent which is indeed a time consuming and costly process. Optimization process may require alteration in formulation composition, manufacturing process, equipment and batch sizes. If these types of changes are applied to a formulation, studies in human healthy volunteers may be required to prove that the new formulation is bioequivalent with the old one.IVIVC includes in vivo relevance to in vitro dissolution specifications and can serve as surrogate for in vivo bioavailability and to support biowaivers. This book provides the information about the use of biorelevant media as media an alternative for in vivo studies.

Biographie de l'auteur

Raman Sureshkumar works in the department of Pharmaceutics JSS College of Pharmacy,Ootacamund affiliated to JSS University Mysore. Thrust area of interest is in enhancing bioavailability of poorly soluble drugs through nanoemulsion technology. To his credit he has published papers in both International and national journals also 2 patents filed.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659440485
ISBN 13 
9783659440489
Reliure
Broché
Nombre de pages
68
Éditeur
Syamala Urmila Sri
Coordonnées du fabricant
non disponible
Personne responsable
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