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Detection of some AML Fusion Genes by Molecular Biology Technique: Haematological Malignancies - Couverture souple

Abbass, Eman

 
9783659446818: Detection of some AML Fusion Genes by Molecular Biology Technique: Haematological Malignancies
Couverture souple
ISBN 10 : 3659446815 ISBN 13 : 9783659446818
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

The diagnosis, prognosis, and treatment of acute myeloid leukemia (AML) has been transformed over the past 15 years from a disease defined, classed, and staged based on histologic characteristics alone to a disease classified largely based on genetic, genomic, and molecular characteristics. The risk pattern in AML is determined not only by cytogenetic abnormalities, such as chromosomal deletions, duplications, or substitutions, but also by the elucidation of certain molecular mutations leading to over- or under-expressions of one of many proteins.This book was aimed to detect the three most frequently occurring reciprocal translocations of(AML) by reverse transcriptase polymerase chain reaction (RT-PCR): AML1-ETO associated with t(8;21), CBFB-MYH11 with inv(16), PML-RARA with t(15;17). The incidence of the common fusion transcripts in our pilot study is in accordance with that described in western studies. It is important to identify these transcripts as they provide useful prognostic information to the treating clinician.This study helps to establish the RT-PCR technique for the first time in the detection of these AML fusion genes,in the molecular biology department in Sudan.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The diagnosis, prognosis, and treatment of acute myeloid leukemia (AML) has been transformed over the past 15 years from a disease defined, classed, and staged based on histologic characteristics alone to a disease classified largely based on genetic, genomic, and molecular characteristics. The risk pattern in AML is determined not only by cytogenetic abnormalities, such as chromosomal deletions, duplications, or substitutions, but also by the elucidation of certain molecular mutations leading to over- or under-expressions of one of many proteins.This book was aimed to detect the three most frequently occurring reciprocal translocations of(AML) by reverse transcriptase polymerase chain reaction (RT-PCR): AML1-ETO associated with t(8;21), CBFB-MYH11 with inv(16), PML-RARA with t(15;17). The incidence of the common fusion transcripts in our pilot study is in accordance with that described in western studies. It is important to identify these transcripts as they provide useful prognostic information to the treating clinician.This study helps to establish the RT-PCR technique for the first time in the detection of these AML fusion genes,in the molecular biology department in Sudan.

Biographie de l'auteur

BSc (MLS), Qualifying year, Institute of Endemic Disease Khartoum University, MSc in Molecular Biology,2013. Worked as Chief Tech. in Molecular Biology Dept (RICK). 2008 received training course in Western General Hospital in Molecular Biology Dept, Edinburgh,UK .Currently CEO in Drive Health Int. Co & Flow cytometry Centre.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659446815
ISBN 13 
9783659446818
Reliure
Broché
Nombre de pages
88
Éditeur
Osman Ihsan, Abdel Gader Abdel Muhsin
Coordonnées du fabricant
non disponible
Personne responsable
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