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Method development for analysis of Amphetamine-type drugs using GC-MS: Forensic Toxicology & drugs Abuse - Couverture souple

Sharma, Mahesh

 
9783659452673: Method development for analysis of Amphetamine-type drugs using GC-MS: Forensic Toxicology & drugs Abuse
Couverture souple
ISBN 10 : 365945267X ISBN 13 : 9783659452673
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Forensic toxicology is the application of toxicology to the matter of law. This work is based on forensic drug testing field of forensic toxicology. Nowadays, the abusing of drugs is considered as a very intense problem which occurring in communities. More and more people are getting addicted to drugs and many are the drug dealers. The main purpose of the present study was the drug profiling and identification of eight Amphetamine-type stimulants (d-amphetamine sulphate, (+)-methamphetamine, Ibuprofen, Piperazine hexahydrate, 1-(4-methoxyphenyl) piperazine, 1-(4-trifluoromethylphenyl) piperazine, 1-Benzylpiperazine and 1-(2-methoxyphenyl) piperazine) by developing a GC-MS method which would detect all the above drugs at the same time. Quinoline was used as internal standard (IS) during the present GC-MS analysis. The first step was the individual drug analysis by the developed GC-MS method and the next step was the mixed drug analysis. The drugs were derivatised by the acylation reagent PFPA, however the silylation reagent BSTFA:TMCS (99:1) was also used as an alternative to acylation. The standard curve of each drug was plotted and the LOD & LOQ was calculated.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Forensic toxicology is the application of toxicology to the matter of law. This work is based on forensic drug testing field of forensic toxicology. Nowadays, the abusing of drugs is considered as a very intense problem which occurring in communities. More and more people are getting addicted to drugs and many are the drug dealers. The main purpose of the present study was the drug profiling and identification of eight Amphetamine-type stimulants (d-amphetamine sulphate, (+)-methamphetamine, Ibuprofen, Piperazine hexahydrate, 1-(4-methoxyphenyl) piperazine, 1-(4-trifluoromethylphenyl) piperazine, 1-Benzylpiperazine and 1-(2-methoxyphenyl) piperazine) by developing a GC-MS method which would detect all the above drugs at the same time. Quinoline was used as internal standard (IS) during the present GC-MS analysis. The first step was the individual drug analysis by the developed GC-MS method and the next step was the mixed drug analysis. The drugs were derivatised by the acylation reagent PFPA, however the silylation reagent BSTFA:TMCS (99:1) was also used as an alternative to acylation. The standard curve of each drug was plotted and the LOD & LOQ was calculated.

Biographie de l'auteur

Forensic Expert & Investigator at SIFS INDIA, Fellow International Science Congress Association,Fellow-SIFS INDIA,M.Sc. in Forensic Science (Cambridge, UK), M.Sc. in Bioinformatics (Delhi,India),Microbiologist + Pharmacist (DAVV-Indore, India)

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
365945267X
ISBN 13 
9783659452673
Reliure
Broché
Nombre de pages
108
Coordonnées du fabricant
non disponible
Personne responsable
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