Development of Controlled Release Three-layered Diclofenac Tablet - Couverture souple

Arafat, Mohammad; Sultana, Farhana; Manirujjaman, -

 
9783659462122: Development of Controlled Release Three-layered Diclofenac Tablet
Couverture souple
ISBN 10 : 3659462128 ISBN 13 : 9783659462122
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Modified release dosage forms offer definite advantages over conventional release formulation of the same drug.The three-layered matrix system overcomes inherent disadvantages of non-linearity associated with the core, covered by two additional layers, each with different rates of swelling, gelling and erosion, is what accounts for the rate of drug release. When the tablet is first swallowed, the drug concentration is high but the surface area is small. As time goes by and the core swells, the surface area expands to compensate for the decrease in drug concentration. Based on these theoretical considerations the three-layered tablets were designed and Diclofenac Sodium, a weakly acidic drug and widely used NSAID, was taken as the model drug to evaluate the comparative release characteristics from different polymer matrices with different amount with the variation in the outer layers as well as in the core.Then the percent release from different batches of Diclofenac Sodium was plotted against time to get the zero order plots. In the zero order plots no true straight lines were obtained but statistically significant differences were found among the release profile.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l'auteur

Mohammad Arafat is a Swedish Institute scholar studying Master's in Biomedicine & Methods in Medical Diagnostics,Experimental Medicine, having a M.S. degree in Pharmaceutical Technology. He worked previously at BDPF of Incepta Pharma. Ltd. Farhana Sultana and Manirujjaman have completed their B.Pharm and M.Pharm degree and engaged in research work.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659462128
ISBN 13 
9783659462122
Reliure
Broché
Nombre de pages
76
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne