Insilico Binding Studies of Phenolic Compounds With Tyrosinase: Vitiligo Is an Acquired Cutaneous Skin Disease Characterized By Declining Melanocyte Function and Depigmentation - Couverture souple

Bhele, Upendra

Couverture souple

ISBN 10 : 3659463744 ISBN 13 : 9783659463747

Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among these the some compounds exhibited significant inhibitory activities against the tyrosinase. Molecular docking studies of these enzymes with those metabolites have been the focus of this study. The active site of the tyrosinase is the two copper ions as binding site. The metal ions seem to play an important role in establishing the interaction within the cavity of active sites. Discovery Studio3.1 was utilized to investigate the conformation and binding affinities of our small molecules. The results indicate a possible mechanism for their anti-tyrosinase activity which may involve anability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.

A propos du livre

À propos de l'auteur

As a Bioinformatics postgraduate (MSc, MTech) Upendra Bhele has worked on various projects as chemoinformatics, pharmacoinformatics and docking studies. He has various research papers under his name

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2013
• Langue: anglais
• ISBN 10: 3659463744
• ISBN 13: 9783659463747
• Reliure: Broché
• Nombre de pages: 96
• Coordonnées du fabricant: non disponible
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