Characterisation of SCCmec Elements in Staphylococci: Characterisation of the mobile genetic element: SCCmec in coagulase negative staphylococci - Couverture souple

Bouchami, Ons

Couverture souple

ISBN 10 : 3659492469 ISBN 13 : 9783659492464

Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

In staphylococci, resistance to β-lactam antibiotics is based on the presence of PBP2a encoded by the mecA gene, which is associated to a mobile genetic element, called the staphylococcal cassette chromosome mec (SCCmec). SCCmec is a genomic island of variable size (range 21-67 Kb), integrated at the 3’ end of the orfX gene, located near the chromosomal origin of replication. The SCCmec is composed of two central elements, the mec complex containing mecA and intact or truncated forms of its regulatory genes (mecI and mecR1) and the ccr complex that contains recombinases responsible for the integration and excision of this element from the chromosome. Up until to now, eleven major types of SCCmec (I-XI) have been identified in S. aureus. In addition, several SCCmec subtypes and SCC non-mec types have been reported. In this study, we provide insights into the molecular epidemiology of coagulase-negative staphylococci other than S. epidermids through the description of the diversity of clonal types and SCC elements. We also provide a detailed analysis on the most likely contribution of S. hominis and S. haemolyticus species to SCCmec evolution.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2014
• Langue: anglais
• ISBN 10: 3659492469
• ISBN 13: 9783659492464
• Reliure: Broché
• Nombre de pages: 228
• Coordonnées du fabricant: non disponible
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