Articles liés à Effects of Demethylation on the Expression of Foxp3...

Effects of Demethylation on the Expression of Foxp3 in T-reg Cells: An investigation on how epigenetic regulation of Foxp3 may influence the stability of regulatory T cell function - Couverture souple

Yao, Edmund

 
9783659495090: Effects of Demethylation on the Expression of Foxp3 in T-reg Cells: An investigation on how epigenetic regulation of Foxp3 may influence the stability of regulatory T cell function
Couverture souple
ISBN 10 : 3659495093 ISBN 13 : 9783659495090
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

CD4+Foxp3+ regulatory T cells (TREG) are pivotal in the maintenance of immune tolerance to self-antigens and act as regulators of autoimmune reactions. There are two subsets of TREG: naturally occurring (nTREG) which develop in the thymus and inducible (iTREG) which are generated from conventional Foxp3- effector T cells (TCONV) in the periphery or in vitro. While both subsets require Foxp3 expression to function, iTREG cells gradually downregulate Foxp3 in vitro and lose their suppressive capabilities. In contrast, nTREG cells show constitutive Foxp3 expression and demonstrate stable suppressive function in vitro. Recent studies reveal a region of the Foxp3 locus that is differentially methylated between nTREG and iTREG. The methylation-sensitive region, known as the TREG-specific demethylated region (TSDR), is completely unmethylated in nTREG, partially methylated in iTREG, and heavily methylated in TCONV, suggesting that differential methylation patterns of the TSDR may account for unstable Foxp3 expression in iTREG. In this study, we investigate whether inhibition of DNMTs and thus methylation, impacts the stability of Foxp3 expression in cultured iTREG.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

CD4+Foxp3+ regulatory T cells (TREG) are pivotal in the maintenance of immune tolerance to self-antigens and act as regulators of autoimmune reactions. There are two subsets of TREG: naturally occurring (nTREG) which develop in the thymus and inducible (iTREG) which are generated from conventional Foxp3- effector T cells (TCONV) in the periphery or in vitro. While both subsets require Foxp3 expression to function, iTREG cells gradually downregulate Foxp3 in vitro and lose their suppressive capabilities. In contrast, nTREG cells show constitutive Foxp3 expression and demonstrate stable suppressive function in vitro. Recent studies reveal a region of the Foxp3 locus that is differentially methylated between nTREG and iTREG. The methylation-sensitive region, known as the TREG-specific demethylated region (TSDR), is completely unmethylated in nTREG, partially methylated in iTREG, and heavily methylated in TCONV, suggesting that differential methylation patterns of the TSDR may account for unstable Foxp3 expression in iTREG. In this study, we investigate whether inhibition of DNMTs and thus methylation, impacts the stability of Foxp3 expression in cultured iTREG.

Biographie de l'auteur

Edmund Yao obtained his B.Sc. and M.Sc. in Immunology at McGill University under the supervision of Dr. Ciriaco Piccirillo. Initially drawn towards the field of immunology because of his food allergy to milk, Edmund now focusses on regulatory CD4+ T cells as his primary area of study.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659495093
ISBN 13 
9783659495090
Reliure
Broché
Nombre de pages
92
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne