Articles liés à Transdermal Patches Of An Antihypertensive Drug: Formulation...

Transdermal Patches Of An Antihypertensive Drug: Formulation And In-vitro Evaluation - Couverture souple

Patil, Shitalkumar; Kardile, Sandip; Patil, Sachinkumar

 
9783659507786: Transdermal Patches Of An Antihypertensive Drug: Formulation And In-vitro Evaluation
Couverture souple
ISBN 10 : 3659507784 ISBN 13 : 9783659507786
Editeur : LAP LAMBERT Academic Publishing, 2013

Synopsis

The main focus of this research work was to develop a matrix type transdermal patch containing Propranolol hydrochloride and combination of two hydrophobic Polymers Eudragit L-100 and Eudragit S-100 by Solvent Evaporation technique.Combination of two Plasticizers Glycerine and Dibutyl phthalate were used and their effect on drug release was studied by changing their concentration in each batch.Methanol and Dichloromethane solvent system was used in which methanol acts as a penetration enhancer.Since oral bioavaibility of Propranolol Hydrochloride is poor due to high first pass metabolism transdermal patch is formed with the objective to get sustained release drug action with good bioavaibility. It can be concluded that the attempt of formulation and evaluation of the propranolol hydrochloride patches was found to be successful in the release of drug for an extended period of time. Further detailed investigations and elaborate in-vivo studies need to be carried out and an in-vitro in-vivo correlation need to established to guarantee the efficiency and bioavaibility of the formulation.

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À propos de l'auteur

Dr, Shitalkumar Patil is working as Professor and Principal in Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Tal. Hatkanangale, Dist. Kolhapur, Maharashtra, India having more than 23 years of experience in Academia and Industry. He has more than 30 publication and 15 presentations in various national and international journals and conferences.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2013
Langue
anglais
ISBN 10 
3659507784
ISBN 13 
9783659507786
Reliure
Broché
Nombre de pages
72
Coordonnées du fabricant
non disponible
Personne responsable
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