Calcium Channel Blockers Against MPTP Induced Parkinson’s In Rats - Couverture souple

Kumar, Puneet; Mehta, Ankita; Deshmukh, Rahul

 
9783659536762: Calcium Channel Blockers Against MPTP Induced Parkinson’s In Rats
Couverture souple
ISBN 10 : 3659536768 ISBN 13 : 9783659536762
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

The present study has been designed to investigate the protective effect of calcium channel blockers against MPTP - induced Parkinson’s disease-like symptoms in rats. The novel protocol showed that repeated bilateral infusion of MPTP into the SNpc by stereotactic surgery caused degeneration of nigrostriatal dopaminergic neurons. Body weight and behavioral parameters (locomotor, rotarod and activity on narrow beam walk) were assessed on 14th, 21st and 28th day post-MPTP administration. Malondialdehyde, nitrite concentration, superoxide dismutase, catalase levels and Cytokines level (TNF-α and IL-1β) were measured on the 28th day. Administration of MPTP significantly impaired behavioral and biochemical parameters, suggesting significant mitochondrial dysfunction as compared to sham control rats. Further, increased level of TNF-α and IL-1β conferred neuroinflammation after MPTP administration in brain. Post treatment with cilnidipine dual L- and N- type and verapamil L-type for 14 days significantly improved behavioral parameters and oxidative damage as compared to MPTP-treated group. Calcium channel blockers treatment also reduced the cytokine levels in brain.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659536768
ISBN 13 
9783659536762
Reliure
Broché
Nombre de pages
84
Coordonnées du fabricant
non disponible
Personne responsable
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