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Formulation and evaluation of ternary dispersion of curcumin: A boon to herbal medicine - Couverture souple

GUPTA, ARUN; KUMAR, ARVIND; Kamboj, Rajwinder

 
9783659548192: Formulation and evaluation of ternary dispersion of curcumin: A boon to herbal medicine
Couverture souple
ISBN 10 : 3659548197 ISBN 13 : 9783659548192
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Curcumin is a yellow-orange powder that is insoluble in water and ether but soluble in ethanol, dimethylsulfoxide, and acetone. Curcuminoids exhibit a broad spectrum of biological and pharmacological activities. Curcumin's unique ability to work through so many different pathways with its extraordinary antioxidant and anti-inflammatory attributes can have a positive influence in combating almost every known disease. In spite of high efficacy and safety, curcumin has not yet been approved as a therapeutic agent, due to the poor solubility and oral bioavailability. Aim of this work is to formulate and evaluate the ternary dispersion (Third Generation Solid Dispersion) of curcumin in order to enhance the dissolution rate by solvent evaporation method (coprecipitation method) with the use of Carrier & Poloxamer. Ternary solid dispersions avoid the drug recrystallization and thus enhance the dissolution rate than Binary solid dispersion.A ternary solid dispersion with solvent evaporation method (coprecipitation method) meets the above requirement to prepare the highly soluble curcumin preparation and comparatively cheaper product ever before.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Curcumin is a yellow-orange powder that is insoluble in water and ether but soluble in ethanol, dimethylsulfoxide, and acetone. Curcuminoids exhibit a broad spectrum of biological and pharmacological activities. Curcumin's unique ability to work through so many different pathways with its extraordinary antioxidant and anti-inflammatory attributes can have a positive influence in combating almost every known disease. In spite of high efficacy and safety, curcumin has not yet been approved as a therapeutic agent, due to the poor solubility and oral bioavailability. Aim of this work is to formulate and evaluate the ternary dispersion (Third Generation Solid Dispersion) of curcumin in order to enhance the dissolution rate by solvent evaporation method (coprecipitation method) with the use of Carrier & Poloxamer. Ternary solid dispersions avoid the drug recrystallization and thus enhance the dissolution rate than Binary solid dispersion.A ternary solid dispersion with solvent evaporation method (coprecipitation method) meets the above requirement to prepare the highly soluble curcumin preparation and comparatively cheaper product ever before.

Biographie de l'auteur

Arun Gupta is presently working as Asst. Professor in S.D.College of pharmacy & Vocational studies, U.P., India. He has also been associated with the different types of research work in the field of pharmaceutics.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659548197
ISBN 13 
9783659548192
Reliure
Broché
Nombre de pages
124
Coordonnées du fabricant
non disponible
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