Formulation and Evaluation of Fast Dissolving Sublingual Tablet: Of Ivabradine Hydrochloride for reduction in ischemic condition in Stable Angina - Couverture souple

Raval, Brahmdutta ; Pujara, Naisarg ; Ranpura, Vicky

9783659595363: Formulation and Evaluation of Fast Dissolving Sublingual Tablet: Of Ivabradine Hydrochloride for reduction in ischemic condition in Stable Angina

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ISBN 10 : 3659595365 ISBN 13 : 9783659595363

Editeur : LAP Lambert Academic Publishing, 2014

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The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristic

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� propos de l?auteur

Brahmdutta Raval, Master of Pharmacy, Pharmaceutics. Studied M. Pharm., Pharmaceutics from N R Vekaria Institute of Pharmacy, Junagadh, Gujarat, India under Gujarat Technological University. Published One Review Article in International Peer Reviewed Journal.

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�diteur: LAP Lambert Academic Publishing
Date d'�dition: 2014
Langue: anglais
ISBN 10: 3659595365
ISBN 13: 9783659595363
Reliure: Broch�
Nombre de pages: 116
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Formulation and Evaluation of Fast Dissolving Sublingual Tablet

Brahmdutta Raval

Edit� par LAP LAMBERT Academic Publishing Aug 2014, 2014

ISBN 10 : 3659595365 ISBN 13 : 9783659595363

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristic 116 pp. Englisch. N� de r�f. du vendeur 9783659595363

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Formulation and Evaluation of Fast Dissolving Sublingual Tablet

Brahmdutta Raval|Naisarg Pujara|Vicky Ranpura

Edit� par LAP LAMBERT Academic Publishing, 2014

ISBN 10 : 3659595365 ISBN 13 : 9783659595363

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Raval BrahmduttaBrahmdutta Raval, Master of Pharmacy, Pharmaceutics. Studied M. Pharm., Pharmaceutics from N R Vekaria Institute of Pharmacy, Junagadh, Gujarat, India under Gujarat Technological University. Published One Review Artic. N� de r�f. du vendeur 5167444

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Formulation and Evaluation of Fast Dissolving Sublingual Tablet

Brahmdutta Raval

Edit� par LAP LAMBERT Academic Publishing Aug 2014, 2014

ISBN 10 : 3659595365 ISBN 13 : 9783659595363

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristicVDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 116 pp. Englisch. N� de r�f. du vendeur 9783659595363

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Formulation and Evaluation of Fast Dissolving Sublingual Tablet : Of Ivabradine Hydrochloride for reduction in ischemic condition in Stable Angina

Brahmdutta Raval

Edit� par LAP LAMBERT Academic Publishing, 2014

ISBN 10 : 3659595365 ISBN 13 : 9783659595363

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The present study was aimed to formulate and evaluate Fast Dissolving Sublingual Tablets of Ivabradine Hydrochloride, a selective If current inhibitor to reduce ischemic condition in Stable Angina. Efficacy of sublingual administration, higher permeability of drug and improvement in bioavailability achievement for drug were the factors that lead to the development of the present work. Compatibility studies of drug and polymer were performed by FTIR and demonstrated no interaction between drug and excipients. Tablets were prepared by direct compression using different concentration of Croscarmellose sodium and Crospovidone. Pre-compression parameters for blend were in the range. Prepared tablets were evaluated for disintegration time, wetting time, Water absorption ratio, %CDR and Ex-vivo permeability study. Formulation F6 (3% CCS, 4.5% CP) was found to be the optimized and showed disintegration time of 25 sec. In vitro drug release was found within 7 minutes and maximum relative permeability from F6 was up to 21 minutes. Dosage form also showed better stability criteria. From the results it was concluded that prepared FDTs executed faster release of IBH with improved characteristic. N� de r�f. du vendeur 9783659595363

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