Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers - Couverture souple

Kobeissy, Firas

 
9783659614941: Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers
Couverture souple
ISBN 10 : 3659614947 ISBN 13 : 9783659614941
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Brain injury can exist in different forms; such conditions occur after mechanical trauma, such as traumatic brain injury (TBI) or after exposure to a number of recreational drugs such as MDMA, methamphetamine, or cocaine. Recent findings have provided some preliminary data showing that brain injury and drug abuse insults may share common pathway(s)leading to neuronal cell injury. Such pathways may be mediated by the activation of the protease families: the pronecrotic calpain and the proapoptotic caspase systems. These proteases can act on a number of substrates including the cytoskeletal proteins resulting in the breakdown products of such proteins can be used as biomarkers for brain injury insult (mechanical and chemical). The field of proteomics has been introduced as a new discipline for biomarker identification that allows for deciphering protein expression at very low concentrations. Having this in mind, neuroproteomics approach has been applied to identify the differential alterations of protein markers involved in two models of experimental traumatic brain injury as well as in drug abuse which showed high similarity in the underlying mechanisms leading to neuronal injury.

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Présentation de l'éditeur

Brain injury can exist in different forms; such conditions occur after mechanical trauma, such as traumatic brain injury (TBI) or after exposure to a number of recreational drugs such as MDMA, methamphetamine, or cocaine. Recent findings have provided some preliminary data showing that brain injury and drug abuse insults may share common pathway(s)leading to neuronal cell injury. Such pathways may be mediated by the activation of the protease families: the pronecrotic calpain and the proapoptotic caspase systems. These proteases can act on a number of substrates including the cytoskeletal proteins resulting in the breakdown products of such proteins can be used as biomarkers for brain injury insult (mechanical and chemical). The field of proteomics has been introduced as a new discipline for biomarker identification that allows for deciphering protein expression at very low concentrations. Having this in mind, neuroproteomics approach has been applied to identify the differential alterations of protein markers involved in two models of experimental traumatic brain injury as well as in drug abuse which showed high similarity in the underlying mechanisms leading to neuronal injury.

Biographie de l'auteur

Dr. Kobeissy is an assistant Professor at the University of Florida, Department of Psychiatry. His research involves studying biomarkers of neuronal cell injury and the role of protease activation in inducing protein breakdown in the area of brain trauma. He is the author of more than 70 articles, reviews, chapter and the editor of 3 books.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659614947
ISBN 13 
9783659614941
Reliure
Broché
Nombre de pages
152
Coordonnées du fabricant
non disponible
Personne responsable
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