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Healing potential of a novel compound isolated from Mentha leaves: Characterization and wound healing activity of a novel compound isolated from Mentha piperita L leaves - Couverture souple

Rais, Iram; Ali, Mohammad

 
9783659615504: Healing potential of a novel compound isolated from Mentha leaves: Characterization and wound healing activity of a novel compound isolated from Mentha piperita L leaves
Couverture souple
ISBN 10 : 3659615501 ISBN 13 : 9783659615504
Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

Phytochemical investigation of the leaves of Mentha piperita (L.) yielded a new compound, which is decarboxyrosemarinic acid galactoside. Formulate as 3’, 4’-dihydroxy-β-phenyl ethyl caffeate-4-(3’’’-menthyl)-4’-β-D-galacto pyranoside. 13C NMR, 1H NMR, FABMS, IR were used for structural characterization. Wound healing responses of this compound was evaluated from biochemical as well as biophysical parameters & analyze the role of isolated compound. The parameters studied included rate of wound contraction & the period of epithelialization in excision wound model. Tissues were removed on different days of intervals and subsequently analyzed for specific assays Tensile strength in incision wound model was assessed along with histopathological examinations. Compound-1 was found to increase the cellular proliferation and collagen synthesis at the wound site, as indicated by increases in amounts of DNA synthesized, protein content. Compound-1treatment was also shown to decrease the levels of lipid peroxides (LPs), while the activity of enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx),were significantly found to be increased when compare to the control.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Phytochemical investigation of the leaves of Mentha piperita (L.) yielded a new compound, which is decarboxyrosemarinic acid galactoside. Formulate as 3’, 4’-dihydroxy-β-phenyl ethyl caffeate-4-(3’’’-menthyl)-4’-β-D-galacto pyranoside. 13C NMR, 1H NMR, FABMS, IR were used for structural characterization. Wound healing responses of this compound was evaluated from biochemical as well as biophysical parameters & analyze the role of isolated compound. The parameters studied included rate of wound contraction & the period of epithelialization in excision wound model. Tissues were removed on different days of intervals and subsequently analyzed for specific assays Tensile strength in incision wound model was assessed along with histopathological examinations. Compound-1 was found to increase the cellular proliferation and collagen synthesis at the wound site, as indicated by increases in amounts of DNA synthesized, protein content. Compound-1treatment was also shown to decrease the levels of lipid peroxides (LPs), while the activity of enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx),were significantly found to be increased when compare to the control.

Biographie de l'auteur

Dr. Iram Rais (Ph.D. Biochemistry),Department of Biochemistry, Faculty of Science, Jamia Hamdard, New Delhi, India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2017
Langue
anglais
ISBN 10 
3659615501
ISBN 13 
9783659615504
Reliure
Broché
Nombre de pages
148
Coordonnées du fabricant
non disponible
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