Articles liés à Anti Diabetics Fast Dissolving Tablet

Anti Diabetics Fast Dissolving Tablet - Couverture souple

Biswal, Pramod Kumar; Bhadouriya, Anupam Singh

 
9783659626999: Anti Diabetics Fast Dissolving Tablet
Couverture souple
ISBN 10 : 3659626996 ISBN 13 : 9783659626999
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Formulation research is oriented towards safty, efficiency and quick onset of action of existing drug molecule through novel concepts of drug delivery. Metformin hydrochloride is an oral antidiabetic biguinide agent, used in the management of non-insulin dependent (type-2) diabetes Mellitus. Orodispersible tablets of Metformin Hcl were prepared by direct compression method. About nine formulations for the present study were carried out based on combination of two superdisintegrants. Croscarmellose sodium, crosspovidone and sodium starch glycolate were used as superdisintegrant. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The formulation containing combination of croscarmellose sodium and sodium starch glycolate showed rapid invitro dispersion time as compared to other formulations. The optimized formulation dispersed in 28 seconds. It also showed a higher water absorption ratio and 98.37% of drug is released within 30 minutes.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Formulation research is oriented towards safty, efficiency and quick onset of action of existing drug molecule through novel concepts of drug delivery. Metformin hydrochloride is an oral antidiabetic biguinide agent, used in the management of non-insulin dependent (type-2) diabetes Mellitus. Orodispersible tablets of Metformin Hcl were prepared by direct compression method. About nine formulations for the present study were carried out based on combination of two superdisintegrants. Croscarmellose sodium, crosspovidone and sodium starch glycolate were used as superdisintegrant. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The formulation containing combination of croscarmellose sodium and sodium starch glycolate showed rapid invitro dispersion time as compared to other formulations. The optimized formulation dispersed in 28 seconds. It also showed a higher water absorption ratio and 98.37% of drug is released within 30 minutes.

Biographie de l'auteur

I am Pramod Kumar Biswal, currently working as Assistant Professor in Kunuwar Haribansh Singh college of Pharmacy, Jaunpur, U.P., India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659626996
ISBN 13 
9783659626999
Reliure
Broché
Nombre de pages
88
Coordonnées du fabricant
non disponible
Personne responsable
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