Formulation Of Drug Delivery Systems Based On Gel-forming Polymers: Preparation and evaluation of degradable, gel-forming Tetracycline HCl films for local treatment of periodontal pockets - Couverture souple

Kassem, Abeer; Ismail, Fatma; Aboulmagd, Elsayed

 
9783659629785: Formulation Of Drug Delivery Systems Based On Gel-forming Polymers: Preparation and evaluation of degradable, gel-forming Tetracycline HCl films for local treatment of periodontal pockets
Couverture souple
ISBN 10 : 3659629782 ISBN 13 : 9783659629785
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of tetracycline HCl (Tc HCl) films based on gel forming polymers as drug release regulators for local treatment of periodontal pockets. Different film formulations were simply prepared by “solvent casting technique”. Films were suitable for intra-pocket application, they were hard enough to be easily inserted into the periodontal pocket. Immediately after application, they hydrate by the action of gingival crevicular fluid forming a bioadhesive gel which allow the formulation to get access to the entire pocket. Films exhibited a sustained release pattern. The stability study for the selected formula (Tc HCl/Na CMC) indicated that the five months storage period did not significantly influence the drug release behavior or its antibacterial activity. Clinical evaluation indicated that the film was well tolerated, no signs of irritation or prolonged foreign body sensation were reported by the test subjects and significant reduction in the pocket depth was observed.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of tetracycline HCl (Tc HCl) films based on gel forming polymers as drug release regulators for local treatment of periodontal pockets. Different film formulations were simply prepared by “solvent casting technique”. Films were suitable for intra-pocket application, they were hard enough to be easily inserted into the periodontal pocket. Immediately after application, they hydrate by the action of gingival crevicular fluid forming a bioadhesive gel which allow the formulation to get access to the entire pocket. Films exhibited a sustained release pattern. The stability study for the selected formula (Tc HCl/Na CMC) indicated that the five months storage period did not significantly influence the drug release behavior or its antibacterial activity. Clinical evaluation indicated that the film was well tolerated, no signs of irritation or prolonged foreign body sensation were reported by the test subjects and significant reduction in the pocket depth was observed.

Biographie de l'auteur

Dr. Abeer Ahmed Kassem. Ph.D. Lecturer of Pharmaceutics, Alexandria, Egypt. Interested in Formulation and Evaluation of Local Drug Delivery Systems for the Treatment of Periodontal Pockets.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659629782
ISBN 13 
9783659629785
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
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