Design and Synthesis of Gd(3+) Based MRI Contrast Agents - Couverture souple

Ur Rashid, Haroon

 
9783659632822: Design and Synthesis of Gd(3+) Based MRI Contrast Agents
Couverture souple
ISBN 10 : 3659632821 ISBN 13 : 9783659632822
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Magnetic Resonance Imaging (MRI) has become a prominent imaging technique in medicine.MRI contrast agents are used to increase the sensitivity of this technique.1,4,7,10-teraazacyclododecane (cyclen) is a key macrocycle used for the synthesis of Magnetic Resonance Imaging (MRI) contrast agents. Substituting the hydrogen atoms (attached to the nitrogen atoms in the ring) of cyclen with suitable groups produce stable ligands. These ligands on complexation with Ln3+ ions lead to the formation of useful chelates. Cyclen is widely synthesized via Richman and Atkins method.Recently, a new method for cancer treatment with a less side effect called photodynamic therapy (PDT) has been introduced. In this method cancer tissues are selectively destroyed without injuring the surrounding healthy cells. However, for the successful use of this method, the selection of an appropriate photosensitizer is important. Hence, it diagnosis-treat union of MRI and PDT will be significantly promoted if a new family of bi-functional agents is found, which would combine the effects of a contrast agent in MRI and of a photosensitizer in PDT. It will bring great improvement to the cancer diagnosis and treatment

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Présentation de l'éditeur

Magnetic Resonance Imaging (MRI) has become a prominent imaging technique in medicine.MRI contrast agents are used to increase the sensitivity of this technique.1,4,7,10-teraazacyclododecane (cyclen) is a key macrocycle used for the synthesis of Magnetic Resonance Imaging (MRI) contrast agents. Substituting the hydrogen atoms (attached to the nitrogen atoms in the ring) of cyclen with suitable groups produce stable ligands. These ligands on complexation with Ln3+ ions lead to the formation of useful chelates. Cyclen is widely synthesized via Richman and Atkins method.Recently, a new method for cancer treatment with a less side effect called photodynamic therapy (PDT) has been introduced. In this method cancer tissues are selectively destroyed without injuring the surrounding healthy cells. However, for the successful use of this method, the selection of an appropriate photosensitizer is important. Hence, it diagnosis-treat union of MRI and PDT will be significantly promoted if a new family of bi-functional agents is found, which would combine the effects of a contrast agent in MRI and of a photosensitizer in PDT. It will bring great improvement to the cancer diagnosis and treatment

Biographie de l'auteur

The author was born (1980) in Swabi, Pakistan.He graduated in Organic Chemistry from University of Peshawar,Pakistan in 2002.He earned his PhD (2012) in Synthetic Organic Chemistry from School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST) Wuhan, China under the superv-ision of Prof. Dr. Kaichao Yu.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659632821
ISBN 13 
9783659632822
Reliure
Broché
Nombre de pages
136
Coordonnées du fabricant
non disponible
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