Articles liés à Controlled Release Injection of a Central Nervous System...

Controlled Release Injection of a Central Nervous System Acting Drug - Couverture souple

Elsayed, Ibrahim; Elshafeey, Ahmed Hassen; Yehia, Soad Ali

 
9783659633386: Controlled Release Injection of a Central Nervous System Acting Drug
Couverture souple
ISBN 10 : 3659633380 ISBN 13 : 9783659633386
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Alzheimer’s disease is a chronic, progressive, neurodegenerative disorder of the brain characterized by deficits in memory and cognitive function. Donepezil is a reversible, noncompetitive cholinesterase inhibitor. It has a high binding specificity for brain acetylcholinesterase, with little to no affinity for butyrylcholinesterase. It is approved by the FDA for the treatment of severe Alzheimer’s disease. The aim of this work is to formulate depot injection lipospheres and in situ implants containing Donepezil for treatment of Alzheimer disease in order to decrease dosing frequency and increase patient compliance. The work is divided into: Chapter 1: Formulation and In Vitro Evaluation of Injectable Donepezil Lipospheres. Chapter 2: Formulation and In Vitro Evaluation of Injectable Donepezil in Situ Implant. Chapter 3: Comparative Pharmacokinetic Study of Different Injectable Donepezil Formulae.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Alzheimer’s disease is a chronic, progressive, neurodegenerative disorder of the brain characterized by deficits in memory and cognitive function. Donepezil is a reversible, noncompetitive cholinesterase inhibitor. It has a high binding specificity for brain acetylcholinesterase, with little to no affinity for butyrylcholinesterase. It is approved by the FDA for the treatment of severe Alzheimer’s disease. The aim of this work is to formulate depot injection lipospheres and in situ implants containing Donepezil for treatment of Alzheimer disease in order to decrease dosing frequency and increase patient compliance. The work is divided into: Chapter 1: Formulation and In Vitro Evaluation of Injectable Donepezil Lipospheres. Chapter 2: Formulation and In Vitro Evaluation of Injectable Donepezil in Situ Implant. Chapter 3: Comparative Pharmacokinetic Study of Different Injectable Donepezil Formulae.

Biographie de l'auteur

Ibrahim Elsayed, PhD in pharmaceutics and industrial pharmacy from Cairo University. Postdoc research in drug delivery. Publications in international journals like; international journal of pharmaceutics and international journal of nanomedicine.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659633380
ISBN 13 
9783659633386
Reliure
Broché
Nombre de pages
292
Coordonnées du fabricant
non disponible
Personne responsable
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